Probe-free optical chromatin deformation and measurement of differential mechanical properties in the nucleus
The nucleus is highly organized to facilitate coordinated gene transcription. Measuring the
rheological properties of the nucleus and its sub-compartments will be crucial to understand …
rheological properties of the nucleus and its sub-compartments will be crucial to understand …
Dynamical phase transition in models that couple chromatin folding with histone modifications
Genomic regions can acquire heritable epigenetic states through unique histone
modifications, which lead to stable gene expression patterns without altering the underlying …
modifications, which lead to stable gene expression patterns without altering the underlying …
Dynamic heterochromatin states in anisotropic nuclei of cells on aligned nanofibers
The cancer cell nucleus deforms as it invades the interstitial spaces in tissues and the tumor
microenvironment. While alteration of the chromatin structure in a deformed nucleus is …
microenvironment. While alteration of the chromatin structure in a deformed nucleus is …
[HTML][HTML] RNA structure promotes liquid-to-solid phase transition of short RNAs in neuronal dysfunction
S Wang, Y Xu - Communications Biology, 2024 - nature.com
In nucleotide expansion disorders, RNA foci are reportedly associated with
neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly …
neurodegenerative disease pathogeneses. Characteristically, these RNAs exhibit long poly …
Ethanol-induced condensation and decondensation in DNA-linked nanoparticles: a nucleosome-like model for the condensed state
Inspired by the conventional use of ethanol to induce DNA precipitation, ethanol
condensation has been applied as a routine method to dynamically tune “bond” lengths (ie …
condensation has been applied as a routine method to dynamically tune “bond” lengths (ie …
Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid-or gel-like dynamical behavior of chromatin
Chromosome organization and dynamics are involved in regulating many fundamental
processes such as gene transcription and DNA repair. Experiments unveiled that chromatin …
processes such as gene transcription and DNA repair. Experiments unveiled that chromatin …
Approaches to characterize chromatin subcompartment organization in the cell nucleus
The mechanism of self-organization of chromatin subcompartments on the 0.1–1 μm scale
and their impact on genome-associated activities has long been a key aspect of research on …
and their impact on genome-associated activities has long been a key aspect of research on …
Non-coding RNAs in chromatin folding and nuclear organization
SV Razin, AA Gavrilov - Cellular and Molecular Life Sciences, 2021 - Springer
One of the most intriguing questions facing modern biology concerns how the genome
directs the construction of cells, tissues, and whole organisms. It is tempting to suggest that …
directs the construction of cells, tissues, and whole organisms. It is tempting to suggest that …
[HTML][HTML] A liquid state perspective on dynamics of chromatin compartments
The interior of the eukaryotic cell nucleus has a crowded and heterogeneous environment
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
packed with chromatin polymers, regulatory proteins, and RNA molecules. Chromatin …
[HTML][HTML] Chromatin: liquid or solid?
A Zidovska - Cell, 2020 - cell.com
In this issue of Cell, Strickfaden et al. reveal that condensed chromatin shows a solid-like
behavior at mesoscales both in vitro and in living cells. Using fluorescent microscopy …
behavior at mesoscales both in vitro and in living cells. Using fluorescent microscopy …