In this article we first present the foundations of ultrafast photoacoustics, a technique where
the acoustic wavelength in play can be considerably shorter than the optical wavelength …

Liquid-liquid phase separation (LLPS) has emerged as a crucial biological mechanism for
sequestering macromolecules (such as proteins and nucleic acids) into membraneless …

Eukaryotic genomes store information on many levels, including their linear DNA sequence,
the posttranslational modifications of its constituents (epigenetic modifications), and its three …

As a hierarchical polymeric scaffold swollen by a high content of water, hydrogels are
transparent, stretchable, dynamic, ionic, and biologically friendly materials that can transmit …

Chromosomes transform during the cell cycle, allowing transcription and replication during
interphase and chromosome segregation during mitosis. Morphological changes are …

The arrangement of nucleosomes inside chromatin is of extensive interest. While in vitro
experiments have revealed the formation of 30 nm fibers, most in vivo studies have failed to …

Precise regulation of gene expression is crucial for plant survival. As a cotranscriptional
regulatory mechanism, pre-mRNA polyadenylation is essential for fine-tuning gene …

How DNA damage and repair processes affect the biomechanical properties of the nucleus
interior remains unknown. Here, an opto-acoustic microscope based on time-domain …

The three-dimensional organisation of the genome modulates biological processes and is,
in turn, transformed by the activity in the nucleus. Not surprisingly, understanding how the …

Transcription is the fundamental process of gene expression, which in eukaryotes occurs
within the complex physicochemical environment of the nucleus. Decades of research have …