Enzymes can be engineered at the level of their amino acid sequences to optimize key
properties such as expression, stability, substrate range, and catalytic efficiency─ or even to …

Artificial intelligence (AI) has been commoditized. It has evolved from a specialty resource to
a readily accessible tool for cancer researchers. AI-based tools can boost research …

Abstract The AlphaFold Database Protein Structure Database (AlphaFold DB,
https://alphafold. ebi. ac. uk) has significantly impacted structural biology by amassing over …

Prediction-powered inference is a framework for performing valid statistical inference when
an experimental dataset is supplemented with predictions from a machine-learning system …

We are now entering a new era in protein sequence and structure annotation, with hundreds
of millions of predicted protein structures made available through the AlphaFold database …

Advanced Artificial Intelligence (AI) enabled large language models (LLMs) to revolutionize
Natural Language Processing (NLP). Their adaptation to protein sequences spawned the …

Proteins are the key molecular machines that orchestrate all biological processes of the cell.
Most proteins fold into three-dimensional shapes that are critical for their function. Studying …

Immune defence mechanisms exist across the tree of life in such diversity that prokaryotic
antiviral responses have historically been considered unrelated to eukaryotic immunity …

Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

Understanding the emergence and structural characteristics of de novo and random proteins
is crucial for unraveling protein evolution and designing novel enzymes. However …