Interferons are cytokines that have antiviral, antiproliferative and immunomodulatory effects.
Because of these important properties, in the past two decades, major research efforts have …

The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription
(STAT) pathway has an important role in the control of immune responses. Dysregulation of …

Hepatic steatosis is a common histological feature of chronic hepatitis C. Various factors are
associated with hepatic steatosis, including obesity, high alcohol consumption, diabetes …

BACKGROUND & AIMS: Silibinin (SIL) is the main flavonoid extracted from milk thistle
(Silibum marianum G). Although widely used for treatment of liver diseases, the efficacy of …

Signal transducers and activators of transcription (STATs) are latent cytoplasmic
transcription factors that mediate various biological responses, including cell proliferation …

Background & Aims: Chronic hepatitis C is a serious global medical problem necessitating
effective treatment. Because standard of care with pegylated interferon plus ribavirin therapy …

The Schlafen (SLFN) family of proteins includes several mouse and human members. There
is emerging evidence that members of this family of proteins are involved in important …

Ulcerative colitis and Crohn's disease are the two entities of chronic inflammatory bowel
diseases (IBD). One of the main pathogenic mechanisms is probably a dysregulated …

Type I interferons (IFNs), IFN-α, IFN-β, IFN-ω, IFN-δ and IFN-τ are a family of structurally
related, species-specific proteins found only in vertebrates. They exhibit a variety of …

The clinical possibilities of interferon (IFN) became apparent with early studies
demonstrating that it was capable of inhibiting tumor cells in culture and in vivo using animal …