The renin‐angiotensin system (RAS) plays essential roles in maintaining peripheral
cardiovascular homeostasis, with its potential roles in the brain only being recognized more …

A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …

Background: Lipid metabolism plays an important role in viral infections. We aimed to
assess the causal effect of lipid-lowering drugs (HMGCR inhibitiors, PCSK9 inhibitiors, and …

Background We aimed to determine whether depressive, anxiety, stress symptoms were
associated with the risk of elevated blood pressure by performing longitudinal cohort and …

Background Schizophrenia (SCZ) is a chronic and severe mental illness with no cure so far.
Mendelian randomization (MR) is a genetic method widely used to explore etiologies of …

Background Mental disorders are among the top causes of disease burden worldwide.
Existing evidence regarding the repurposing of antihypertensives for mental disorders …

Blood pressure is regulated by a complex neurohumoral system including the renin-
angiotensin-aldosterone system, natriuretic peptides, endothelial pathways, the sympathetic …

Observational studies and randomized controlled trials presented inconsistent findings on
the effects of cholesterol-lowering statins on depression. It therefore remains unclear …

Background and hypothesis Psychiatric disorders impose a huge health and economic
burden on modern society. However, there is currently no proven completely effective …

Objective: Inflammatory cytokines disturbance is the main result of immune dysregulation,
which is widely described in major depressive disorder (MDD). However, the potential …