Small molecular fluorescent probes for Alzheimer's disease associated active species

F Tang, K Wang, X Liu, X Zhang, W Zhou… - … A European Journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and is the main
cause of dementia worldwide. As the pathogenesis of AD is quite complicated, there is …

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

MC Cabello, G Chen, MJ Melville, R Osman… - Chemical …, 2024 - ACS Publications
Reactive oxygen and nitrogen species are small reactive molecules derived from elements
in the air─ oxygen and nitrogen. They are produced in biological systems to mediate …

An ESIPT-based ratiometric fluorescent probe for detecting H2O2 in water environment and biosystems

Z Li, L Xiao, X Sun, C Luo, R Li, W Zhang… - Science of the Total …, 2023 - Elsevier
The outbreak of the COVID-19 has resulted in a great increase in the use of H 2 O 2
disinfectant, which is listed as one of the commonly used disinfectants for COVID-19 by the …

Rational construction and evaluation of a dual-functional near-infrared fluorescent probe for the imaging of Amyloid-β and mitochondrial viscosity

Y Cao, S Xu, J Liu, S Zhao, J Yan - … Acta Part A: Molecular and Biomolecular …, 2024 - Elsevier
Alzheimer's disease is a fatal, incurable, chronic neurodegenerative disease. Diagnosis in
its early and even preclinical stages will be beneficial for its prevention and treatment. In the …

An epoxide-based covalent sensor to detect cardiac proteome aggregation in a cardio-oncology model

H Jin, D Shen, B Jing, Z Zhang, Z Wang, R Sun… - Analytica Chimica …, 2023 - Elsevier
Covalent sensors to detect and capture aggregated proteome in stressed cells are rare.
Herein, we construct a series of covalent fluorogenic sensors for aggregated proteins by …

Rofecoxib derivatives as NIR fluorescent probes for mitochondrial viscosity and in vivo imaging of Aβ plaques

G Anwar, D Chen, Q Chen, C Xia, J Yan - Spectrochimica Acta Part A …, 2024 - Elsevier
Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder for which the
underlying causes remain largely unknown. Therefore, the development of imaging agents …

A near-infrared fluorescent probe for tracking endogenous and exogenous H2O2 in cells and zebrafish

Y Wu, F Jing, H Huang, H Wang, S Chen, W Fan… - … Acta Part A: Molecular …, 2023 - Elsevier
H 2 O 2 is an important signaling molecule in the body, and its levels fluctuate in many
pathological sites, therefore, it can be used as a biomarker for early diagnosis of disease …

Development of BODIPY-based fluorescent probes for imaging Aβ aggregates and lipid droplet viscosity

K Li, Y Wang, Y Li, W Shi, J Yan - Talanta, 2024 - Elsevier
Abstract Alzheimer's disease (AD), gradually recognized as an untreatable
neurodegenerative disorder, has been considered to be closely associated with Aβ plaques …

Novel pyrrolidine-alkylamino-substituted dicyanoisophorone derivatives as near-infrared fluorescence probe for imaging β-amyloid in vitro and in vivo

H Zhou, J Zhai, H Gong, R Fang, Y Zhao, W Luo - Analytica Chimica Acta, 2024 - Elsevier
Background The formation of amyloid-β (Aβ) plaques is one of the key neuropathological
hallmarks of Alzheimer's disease (AD). Near-infrared (NIR) probes show great potential for …

A near-infrared fluorescent probe based FRET for ratiometric sensing of H2O2 and viscosity in live cells

FT Liu, S Wang, YP Wang, PF Jiang, JY Miao, BX Zhao… - Talanta, 2024 - Elsevier
Abstract Hydrogen peroxide (H 2 O 2) and viscosity play vital roles in the cellular
environment as signaling molecule and microenvironment parameter, respectively, and are …