Lipids uniquely alter the secondary structure and toxicity of amyloid beta 1–42 aggregates
K Zhaliazka, M Matveyenka, D Kurouski - The FEBS journal, 2023 - Wiley Online Library
Abrupt aggregation of amyloid β1‐42 (Aβ) peptide is a hallmark of Alzheimer's disease (AD),
a severe pathology that affects more than 44 million people worldwide. A growing body of …
a severe pathology that affects more than 44 million people worldwide. A growing body of …
Elucidating the Role of Lipids in the Aggregation of Amyloidogenic Proteins
D Kurouski - Accounts of Chemical Research, 2023 - ACS Publications
Conspectus The abrupt aggregation of misfolded proteins is linked to the onset and spread
of amyloidogenic diseases, including diabetes type 2, systemic amyloidosis, and …
of amyloidogenic diseases, including diabetes type 2, systemic amyloidosis, and …
Role of saturation and length of fatty acids of phosphatidylserine in the aggregation of transthyretin
The progressive accumulation of transthyretin (TTR), a small protein that transports
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
thyroxine, in various organs and tissues is observed upon transthyretin amyloidosis, a …
The influence of Zwitterionic and anionic phospholipids on protein aggregation
The progressive aggregation of misfolded proteins is the underlying molecular cause of
numerous pathologies including Parkinson's disease and injection and transthyretin …
numerous pathologies including Parkinson's disease and injection and transthyretin …
Phospholipids and Cholesterol Determine Molecular Mechanisms of Cytotoxicity of α-Synuclein Oligomers and Fibrils
K Zhaliazka, A Ali, D Kurouski - ACS Chemical Neuroscience, 2024 - ACS Publications
Progressive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta,
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
hypothalamus, and thalamus is a hallmark of Parkinson's disease. Neuronal death is linked …
Secondary structure and toxicity of transthyretin fibrils can be altered by unsaturated fatty acids
Transthyretin amyloidosis is a severe pathology characterized by the progressive
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
accumulation of transthyretin (TTR) in various organs and tissues. This highly conserved …
Saturation of fatty acids in phosphatidic acid uniquely alters transthyretin stability changing morphology and toxicity of amyloid fibrils
Transthyretin (TTR) is a small, β-sheet-rich tetrameric protein that transports thyroid hormone
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
thyroxine and retinol. Phospholipids, including phosphatidic acid (PA), can uniquely alter the …
[HTML][HTML] Unsaturated fatty acids uniquely alter aggregation rate of α-synuclein and insulin and change the secondary structure and toxicity of amyloid aggregates …
M Matveyenka, K Zhaliazka… - FASEB journal: official …, 2023 - ncbi.nlm.nih.gov
Docosahexaenoic (DHA) and arachidonic acids (ARA) are omega-3 and omega-6 long-
chain polyunsaturated fatty acids (LCPUFAs). These molecules constitute a substantial …
chain polyunsaturated fatty acids (LCPUFAs). These molecules constitute a substantial …
Length and saturation of choline plasmalogens alter the aggregation rate of α-synuclein but not the toxicity of amyloid fibrils
Plasmalogens comprise a large fraction of the total phospholipids in plasma membranes.
These molecules modulate membrane fluidity, produce inflammatory mediators mitigating …
These molecules modulate membrane fluidity, produce inflammatory mediators mitigating …
Length and saturation of fatty acids in phosphatidylserine determine the rate of lysozyme aggregation simultaneously altering the structure and toxicity of amyloid …
A Frese, C Goode, K Zhaliazka, AP Holman… - Protein …, 2023 - Wiley Online Library
Abrupt aggregation of misfolded proteins is the underlying molecular cause of numerous
severe pathologies including Alzheimer's and Parkinson's diseases. Protein aggregation …
severe pathologies including Alzheimer's and Parkinson's diseases. Protein aggregation …