The rule of 5 (Ro5) is a set of in silico guidelines applied to drug discovery to prioritize
compounds with an increased likelihood of high oral absorption. It has been influential in …

Tuberculosis (TB) is the world's second leading infectious killer. Cases of multidrug-resistant
(MDR-TB) and extremely drug-resistant (XDR-TB) have increased globally. Therapeutic …

Therapeutic drug monitoring (TDM) is a standard clinical technique used for many disease
states, including many infectious diseases. As for these other conditions, the use of TDM in …

Tuberculosis (TB) is the second most deadly infectious disease. Despite potentially curative
pharmacotherapies being available for over 50years, the length of the treatment and the pill …

Bioavailability of orally administered drugs can be influenced by a number of factors
including release from the formulation, dissolution, stability in the gastrointestinal (GI) …

Rifampin has concentration-dependent activity against Mycobacterium tuberculosis.
However, marked intersubject variation of rifampin concentrations occurs. In this study, we …

Abstract A Mycobacterium tuberculosis (H37Rv)-infected guinea pig model was used to
screen for targeted delivery to the lungs by insufflation (with lactose excipient) or …

The present study describes comparative bioavailability of rifampicin (RIF) after
administration of a single component RIF (450 mg) capsule and rifampicin-isoniazid (RIF …

With almost 30% of the world population suffering from tuberculosis (TB) including its
resurgence in the developed world, better management of this global threat is highly …

Clinically significant interactions occurring during antituberculous chemotherapy principally
involve rifampicin (rifampin), isoniazid and the fluoroquinolones. Such interactions between …