Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …
Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy
Y Liu, Z Xun, K Ma, S Liang, X Li, S Zhou, L Sun… - Journal of …, 2023 - Elsevier
Background & Aims The tumour microenvironment (TME) is a crucial mediator of cancer
progression and therapeutic outcome. The TME subtype correlates with patient response to …
progression and therapeutic outcome. The TME subtype correlates with patient response to …
Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …
Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer
F Wu, J Fan, Y He, A Xiong, J Yu, Y Li, Y Zhang… - Nature …, 2021 - nature.com
Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …
microenvironment together determine disease progression, as well as response to or …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes
Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …
remains challenging to distinguish normal cell types in the tumor microenvironment from …
The updated landscape of tumor microenvironment and drug repurposing
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …
[PDF][PDF] Emerging immunotherapy for HCC: A guide for hepatologists
HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …