Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Immunotherapies for hepatocellular carcinoma

JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

Liver tumour immune microenvironment subtypes and neutrophil heterogeneity

R Xue, Q Zhang, Q Cao, R Kong, X Xiang, H Liu… - Nature, 2022 - nature.com
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and …

Identification of a tumour immune barrier in the HCC microenvironment that determines the efficacy of immunotherapy

Y Liu, Z Xun, K Ma, S Liang, X Li, S Zhou, L Sun… - Journal of …, 2023 - Elsevier
Background & Aims The tumour microenvironment (TME) is a crucial mediator of cancer
progression and therapeutic outcome. The TME subtype correlates with patient response to …

Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance

Y Chu, E Dai, Y Li, G Han, G Pei, DR Ingram… - Nature medicine, 2023 - nature.com
Tumor-infiltrating T cells offer a promising avenue for cancer treatment, yet their states
remain to be fully characterized. Here we present a single-cell atlas of T cells from 308,048 …

Single-cell profiling of tumor heterogeneity and the microenvironment in advanced non-small cell lung cancer

F Wu, J Fan, Y He, A Xiong, J Yu, Y Li, Y Zhang… - Nature …, 2021 - nature.com
Lung cancer is a highly heterogeneous disease. Cancer cells and cells within the tumor
microenvironment together determine disease progression, as well as response to or …

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma

Y Sun, L Wu, YU Zhong, K Zhou, Y Hou, Z Wang… - Cell, 2021 - cell.com
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …

Delineating copy number and clonal substructure in human tumors from single-cell transcriptomes

R Gao, S Bai, YC Henderson, Y Lin, A Schalck… - Nature …, 2021 - nature.com
Single-cell transcriptomic analysis is widely used to study human tumors. However, it
remains challenging to distinguish normal cell types in the tumor microenvironment from …

The updated landscape of tumor microenvironment and drug repurposing

MZ Jin, WL Jin - Signal transduction and targeted therapy, 2020 - nature.com
Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

[PDF][PDF] Emerging immunotherapy for HCC: A guide for hepatologists

F Foerster, SJ Gairing, SI Ilyas, PR Galle - Hepatology, 2022 - Wiley Online Library
HCC is one of the most common cancers worldwide, and the third leading cause of cancer‐
related death globally. HCC comprises nearly 90% of all cases of primary liver cancer …