Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the
mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a …

Retinitis pigmentosa (RP) and Leber congenital amaurosis (LCA) are inherited degenerative
retinal dystrophies with vision loss that ultimately lead to blindness. Several genes have …

Retinal dystrophies (RDs) comprise relatively rare but devastating causes of progressive
vision loss. They represent a spectrum of diseases with marked genetic and clinical …

Variations in the Crumbs homolog-1 (CRB1) gene are associated with a wide variety of
autosomal recessive retinal dystrophies, including early onset retinitis pigmentosa (RP) and …

Purpose To investigate the retinal structure and function in patients with CRB1‐associated
retinal dystrophies (RD) and to explore potential clinical endpoints. Methods In this …

Crumbs homolog 1 (CRB1) is one of the key genes linked to retinitis pigmentosa and Leber
congenital amaurosis, which are characterized by a high clinical heterogeneity. The Crumbs …

The present invention relates to a Crumbs homologue (CRB) therapeutic for use as a
medicament or in a method of treatment or prophylaxis, for example in the treatment or …

Mutations in the Crumbs homolog 1 (CRB1) gene lead to severe inherited retinal
dystrophies (IRDs), accounting for nearly 80,000 cases worldwide. To date, there is no …

Mutations in the Crumbs homologue 1 (CRB1) gene cause inherited retinal dystrophies,
such as early-onset retinitis pigmentosa and Leber congenital amaurosis. A Brown Norway …

The Crumbs protein (CRB) family plays a crucial role in maintaining the apical–basal
polarity and integrity of embryonic epithelia. The family comprises different isoforms in …