Background: Mutations in the Crumbs homolog-1 (CRB1) gene are associated with a variety
of retinal degenerations including Leber congenital amaurosis (LCA) and retinitis …

SUMMARY CRB1 gene mutations can cause early-or late-onset retinitis pigmentosa, Leber
congenital amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in animal …

Apical-basal cell polarity is crucial for the development of multicellular organisms and for the
diverse functions of epithelial cells in diverse organs. Cell polarity in epithelial cells is …

ARRP autosomal recessive retinitis pigmentosa AZOOR acute zonal occult outer retinopathy
BCVA best-corrected visual acuity BCEA bivariate contour ellipse area CF counting fingers …

Résumé Introduction. La distribution asymétrique des composantes cellulaires au sein des
cellules épithéliales résulte en une polarité apico-basale, laquelle divise la cellule en un …

SUMMARY CRB1 gene mutations can cause early-or late-onset retinitis pigmentosa, Leber
congenital amaurosis, or maculopathy. Recapitulating human CRB1 phenotypes in animal …

Using human induced pluripotent stem cell (hiPSC)-derived models for ophthalmology
research is an emerging strategy to explore patient phenotypes in vitro, which allows access …

Retinitis pigmentosa and Leber congenital amaurosis are inherited retinal dystrophies that
can be caused by mutations in the Crumbs homolog 1 (CRB1) gene. CRB1 is required for …

Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the
mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a …