All surgical disciplines encounter planned and unplanned ischemic events that may
ultimately lead to cellular dysfunction and death. Stem cell therapy has shown promise for …

Cell therapy now constitutes an important area of regenerative medicine. The aging of the
population has mandated the discovery and development of new and innovative therapeutic …

Sex-related differences are a current topic in contemporary science. In addition to hormonal
regulation, cell-autonomous mechanisms are important in bone homeostasis and …

Introduction Studies from our group and others have indicated that paracrine function is one
of major mechanisms underlying stem cell-mediated cardioprotection. To improve …

Background No medical therapies are yet available to slow abdominal aortic aneurysm
(AAA) growth. This study sought to investigate the effect of different genders of bone marrow …

Differences in cardiovascular disease outcomes between men and women have long been
recognized and attributed, in part, to gender and sex steroids. Gender dimorphisms also …

Background aims Mesenchymal stromal cells (MSCs) have shown great promise for cell
therapy of a wide range of diseases such as diabetes. However, insufficient viability of …

Mesenchymal stem cells (MSCs) may offer therapeutic benefit in the setting of sepsis and
endotoxemia. Previous studies suggest that MSCs from female donors may possess better …

Muscle-derived stem cells (MDSCs) are known to exhibit sexual dimorphism, by donor sex,
of osteogenic, chondrogenic, and myogenic differentiation potential in vitro. Moreover, host …

Sexual dimorphisms contribute, at least in part, to the severity and occurrence of a broad
range of neurodegenerative, cardiovascular, and bone disorders. In addition to hormonal …