[HTML][HTML] Osteoarthritis as an Enhanceropathy: Gene Regulation in Complex Musculoskeletal Disease
JB Roberts, SJ Rice - Current Rheumatology Reports, 2024 - Springer
Abstract Purpose of Review Osteoarthritis is a complex and highly polygenic disease. Over
100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly …
100 reported osteoarthritis risk variants fall in non-coding regions of the genome, ostensibly …
[HTML][HTML] Epigenetic mechanisms of osteoarthritis risk in human skeletal development
The epigenome, including the methylation of cytosine bases at CG dinucleotides, is
intrinsically linked to transcriptional regulation. The tight regulation of gene expression …
intrinsically linked to transcriptional regulation. The tight regulation of gene expression …
Molecular Structure and Enzymatic Mechanism of the Human Collagen Hydroxylysine Galactosyltransferase GLT25D1/COLGALT1
M De Marco, SR Rai, L Scietti, D Mattoteia, S Liberi… - bioRxiv, 2024 - biorxiv.org
During biosynthesis, collagen lysine residues undergo extensive post-translational
modifications essential for the stability and functions of collagen supramolecular assemblies …
modifications essential for the stability and functions of collagen supramolecular assemblies …
[PDF][PDF] Identifying causal brain structures and proteins for osteoarthritis: A large-scale genetic correlation study based on brain imaging-derived phenotypes …
S Zhao, C Wang, Z Liu, Y Zhu, Z Ruan, H Long, Z Lin… - 2024 - scholar.archive.org
This study aimed to validate the causal associations of brain structures with osteoarthritis
(OA) and then describe key causal genes and proteins in brain related to OA risk. To explore …
(OA) and then describe key causal genes and proteins in brain related to OA risk. To explore …