Usefulness and analytical performances of complement multiplex assay for measuring complement biomarkers in plasma

MS Meuleman, A Duval, A Grunenwald, MR Artero… - Clinica Chimica …, 2024 - Elsevier
Introduction The complement system is involved in numerous diseases, through diverse
mechanisms and degree of activation. With the emergence of complement targeting …

Identification of inflammatory biomarkers in IgA nephropathy using the NanoString technology: a validation study in Caucasians

L Gaumond, C Lamarche, S Beauchemin… - Inflammation …, 2024 - Springer
Objective and design Immunoglobulin A nephropathy (IgAN) is a kidney disease
characterized by the accumulation of IgA deposits in the glomeruli of the kidney, leading to …

A new alternative: inhibiting complement activation in patients with IgA nephropathy

J Floege - Kidney International, 2024 - Elsevier
Mesangial complement C3 deposits, reflecting alternative and possibly lectin pathway
activation, are characteristic in biopsies of patients with IgA nephropathy (IgAN). A recent …

# 1021 A phase 3 randomized controlled trial of ravulizumab in adult patients with IgA nephropathy

H Trimarchi, J Barratt, HL Heerspink… - Nephrology Dialysis …, 2024 - academic.oup.com
Abstract Background and Aims The pathogenesis of IgA nephropathy (IgAN) includes the
deposition of immune complexes in the kidney and activation of the complement system …

Die Komplementkaskade in der Nierenpathologie

E Vonbrunn, C Daniel - Die Pathologie, 2024 - Springer
Zusammenfassung Die Komplementkaskade umfasst eine Vielzahl von löslichen und
gebundenen Proteinen und ist ein wichtiger Bestandteil des angeborenen Immunsystems …

[图书][B] Pathogenesis of IgA nephropathy and diabetic kidney disease: linking molecular profile to morphological and clinical picture

A Levin - 2024 - openarchive.ki.se
Background: More than 10% of the global population suffers from chronic kidney disease
(CKD), which poses a large impact on society and, more importantly, the life of the affected …

IgA-Nephropathie

J Floege - Die Urologie, 2024 - Springer
Zusammenfassung Die IgA-Nephropathie (IgAN) ist die häufigste primäre
Glomerulonephritisform. Die Ursache ist teilweise verstanden und liegt offenbar im …