During aging, the cellular milieu of the brain exhibits tell-tale signs of compromised
bioenergetics, impaired adaptive neuroplasticity and resilience, aberrant neuronal network …

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

Cells are programmed to favorably respond towards the nutrient availability by adapting
their metabolism to meet energy demands. AMP-activated protein kinase (AMPK) is a highly …

AMP-activated protein kinase (AMPK) is a crucial cellular energy sensor. Once activated by
falling energy status, it promotes ATP production by increasing the activity or expression of …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status. It is
activated, by a mechanism requiring the tumor suppressor LKB1, by metabolic stresses that …

Living cells obtain energy either by oxidizing reduced compounds of organic or mineral
origin or by absorbing light. Whichever energy source is used, some of the energy released …

Parkinson's disease (PD) is a neurodegenerative disorder characterized by selective loss of
dopaminergic neurons in the substantia nigra pars compacta (SNpc) region of the midbrain …

Membrane contacts between endoplasmic reticulum (ER) and plasma membrane (PM), or
ER-PM junctions, are ubiquitous in eukaryotic cells and are platforms for lipid and calcium …

Kv2 family “delayed-rectifier” potassium channels are widely expressed in mammalian
neurons. Kv2 channels activate relatively slowly and their contribution to action potential …

Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …