Inflammasomes play a crucial role in innate immunity by serving as signaling platforms
which deal with a plethora of pathogenic products and cellular products associated with …

TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of
human diseases. A few compounds have been developed to inhibit NLRP3 inflammasome …

This report describes a number of substructural features which can help to identify
compounds that appear as frequent hitters (promiscuous compounds) in many biochemical …

Bone marrow‐derived mesenchymal stem cell (BM‐MSC) transplantation has been
suggested as an effective therapy for liver cirrhosis. The efficacy and safety of autologous …

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in the gene encoding the
CF transmembrane conductance regulator (CFTR), a protein kinase A (PKA)-activated …

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …

Identification of Lgr5 as the intestinal stem cell marker as well as the growth factors
necessary to replicate adult intestinal stem cell division has led to the establishment of the …

Clinically significant antibiotic resistance has evolved against virtually every antibiotic
deployed. Yet the development of new classes of antibiotics has lagged far behind our …

The diversity in the biological response of 4-thiazolidinones has attracted the attention of
many researchers to explore this framework for its potential. It is, therefore, of prime …