Stevioside and related compounds: therapeutic benefits beyond sweetness

V Chatsudthipong, C Muanprasat - Pharmacology & therapeutics, 2009 - Elsevier
Stevioside, an abundant component of Stevia rebaudiana leaf, has become well-known for
its intense sweetness (250–300 times sweeter than sucrose) and is used as a non-caloric …

Modulation of glucose metabolism by the renin-angiotensin-aldosterone system

GA Favre, VLM Esnault… - American Journal of …, 2015 - journals.physiology.org
The renin-angiotensin-aldosterone system (RAAS) is an enzymatic cascade functioning in a
paracrine and autocrine fashion. In animals and humans, RAAS intrinsic to tissues …

Streptozotocin‐induced diabetic models in mice and rats

BL Furman - Current protocols in pharmacology, 2015 - Wiley Online Library
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β‐cell destruction and is
widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed …

Streptozotocin‐induced diabetic models in mice and rats

BL Furman - Current protocols, 2021 - Wiley Online Library
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β‐cell destruction and is
widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed …

Streptozotocin‐induced diabetic models in mice and rats

KK Wu, Y Huan - Current protocols in pharmacology, 2008 - Wiley Online Library
Streptozotocin (STZ) is an antibiotic that can cause pancreatic β‐cell destruction, so it is
widely used experimentally as an agent capable of inducing insulin‐dependent diabetes …

Mechanism of the hypoglycemic effect of stevioside, a glycoside of Stevia rebaudiana

TH Chen, SC Chen, P Chan, YL Chu, HY Yang… - Planta …, 2005 - thieme-connect.com
We have studied the effects of stevioside on the glucose and insulin metabolism in 2 models
of diabetes in rats, STZ-induced diabetic rats and NIDDM diabetic rats induced by feeding …

Phosphatidylinositol-3-kinase is involved in the antihyperglycemic effect induced by resveratrol in streptozotocin-induced diabetic rats

TC Chi, WP Chen, TL Chi, TF Kuo, SS Lee, JT Cheng… - Life sciences, 2007 - Elsevier
Resveratrol, a polyphenolic substance found in grape skin, is proposed to account in part for
the protective effect of red wine in the cardiovascular system. The aim of the present study is …

Antihyperglycemic activity of Tarralin™, an ethanolic extract of Artemisia dracunculus L.

DM Ribnicky, A Poulev, M Watford, WT Cefalu, I Raskin - Phytomedicine, 2006 - Elsevier
The studies reported here were undertaken to examine the antihyperglycemic activity of an
ethanolic extract of Artemisia dracunculus L., called Tarralin™ in diabetic and non-diabetic …

Treating the metabolic syndrome: telmisartan as a peroxisome proliferator-activated receptor-gamma activator

TW Kurtz - Acta Diabetologica, 2005 - Springer
Hypertension commonly occurs as part of a genetically complex disorder of carbohydrate
and lipid metabolism known as the metabolic syndrome. Most current antihypertensive …

Towards multi-target antidiabetic agents: Discovery of biphenyl-benzimidazole conjugates as AMPK activators

DA Babkov, ON Zhukowskaya, AV Borisov… - Bioorganic & medicinal …, 2019 - Elsevier
Type 2 diabetes mellitus is a complex metabolic disorder requiring polypharmacology
approaches for effective treatment. Combinatorial library of fifteen new tricyclic …