[HTML][HTML] The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the …
Update on the role of glucocorticoid signaling in osteoblasts and bone marrow adipocytes during aging
H Bensreti, DW Alhamad, AM Gonzalez… - Current osteoporosis …, 2023 - Springer
Abstract Purpose of Review Bone marrow adipose tissue (BMAT) in the skeleton likely plays
a variety of physiological and pathophysiological roles that are not yet fully understood. In …
a variety of physiological and pathophysiological roles that are not yet fully understood. In …
[HTML][HTML] Clinical utility of mifepristone: apprising the expanding horizons
ZV Karena, H Shah, H Vaghela, K Chauhan, PK Desai… - Cureus, 2022 - ncbi.nlm.nih.gov
Mifepristone is a progesterone and glucocorticoid receptor antagonist. Medical abortion with
mifepristone and prostaglandin has revolutionized the abortion process extending abortion …
mifepristone and prostaglandin has revolutionized the abortion process extending abortion …
FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder
Post-traumatic stress disorder (PTSD) leads to enhanced alcohol drinking and development
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
of alcohol use disorder (AUD). Identifying shared neural mechanisms might help discover …
Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic …
Post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD) are often comorbid.
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
Few treatments exist to reduce comorbid PTSD/AUD. Elucidating the mechanisms …
Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit/stress surfeit disorder
GF Koob, L Vendruscolo - 2023 - Springer
Alcohol use disorder (AUD) can be defined by a compulsion to seek and take alcohol, the
loss of control in limiting intake, and the emergence of a negative emotional state when …
loss of control in limiting intake, and the emergence of a negative emotional state when …
[HTML][HTML] Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats
Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms …
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms …
IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder
Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
dysregulated neuroimmune-related pathways. Here, we used our established rat model of …
Alcohol dependence induces CRF sensitivity in female central amygdala GABA synapses
Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of
control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress …
control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress …
The effect of chronic alcohol exposure on spatial memory and BDNF–TrkB-PLCγ1 signaling in the hippocampus of male and female mice
J Ma, F Xiong, Z Li, G Dong, X Sun, W Yin, H Cai - Heliyon, 2023 - cell.com
Alcohol is a commonly used drug worldwide, and abuse of alcohol has become a serious
public health problem. Alcohol consumption over time can cause cognitive deficits and …
public health problem. Alcohol consumption over time can cause cognitive deficits and …