Strategies and clinical implications of chimerism diagnostics after allogeneic hematopoietic stem cell transplantation

C Thiede, M Bornhäuser, G Ehninger - Acta haematologica, 2004 - karger.com
Abstract Analysis of donor chimerism has become a routine method for the documentation of
engraftment after allogeneic hematopoietic stem cell transplantation (HSCT). In recent years …

Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation (BSCT) using multiplex PCR …

C Thiede, M Bornhäuser, U Oelschlägel, C Brendel… - Leukemia, 2001 - nature.com
Sequential analysis of chimerism after allogeneic blood stem cell transplantation (BSCT)
has been shown to be predictive for graft failure and relapse. We have explored the impact …

Allogeneic stem cell transplantation for chronic myeloid leukemia

J Barrett - Seminars in hematology, 2003 - Elsevier
Allogeneic stem cell transplantation (SCT) plays a central role in chronic myeloid leukemia
(CML) because it remains the only treatment with proven curative potential. For this reason …

Molecular analysis of lineage-specific chimerism and minimal residual disease by RT-PCR of p210BCR-ABL and p190BCR-ABL after allogeneic bone marrow transplantation …

J Serrano, J Roman, J Sanchez… - Blood, The Journal …, 2000 - ashpublications.org
We studied lineage-specific chimerism and minimal residual disease (MRD) in sequential
posttransplant samples from 55 patients who underwent unmanipulated (n= 44) or partially T …

Mixed hematopoietic chimerism at day 90 following allogenic myeloablative stem cell transplantation is a predictor of relapse and survival

R Lamba, E Abella, D Kukuruga, J Klein, S Savasan… - Leukemia, 2004 - nature.com
We retrospectively analyzed the prognostic significance of mixed chimerism and associated
clinical parameters in 80 patients following unmanipulated allogenic stem cell …

Serial quantification of lymphoid and myeloid mixed chimerism using multiplex PCR amplification of short tandem repeat-markers predicts graft rejection and relapse …

F Fernandez-Aviles, A Urbano-Ispizua, M Aymerich… - Leukemia, 2003 - nature.com
We used multiplex amplification of nine microsatellite sequences (PCR-STR) to analyse
chimerism in pure populations of T cells and neutrophils from peripheral blood from 40 …

Molecular basis for therapeutic decisions in chronic myeloid leukemia patients after allogeneic bone marrow transplantation

J Roman, MA Alvarez, A Torres - Haematologica, 2000 - haematologica.org
BACKGROUND AND OBJECTIVES: Recent progress in the development of diagnostic
techniques has greatly facilitated the monitoring of minimal residual disease (MRD) in …

Morphology of the bone marrow after stem cell transplantation

AMW Van Marion, J Thiele, HM Kvasnicka… - …, 2006 - Wiley Online Library
In many haematological conditions the only curative option is stem cell (SCT) or bone
marrow (BM) transplantation. Little information exists about BM morphology following non …

MIXED CHIMERISM OF THE RESIDENT MACROPHAGE POPULATION AFTER ALLOGENEIC BONE MARROW TRANSPLANTATION FOR CHRONIC MYELOID …

C Wickenhauser, J Thiele, F Pérez, E Varus… - …, 2002 - journals.lww.com
Background. Bone marrow macrophages have been recognized to play a crucial role in the
functional network that constitutes the microenvironment. In chronic myelogenous leukemia …

Increasing mixed haematopoietic chimaerism after BMT with total depletion of CD4+ and partial depletion of CD8+ lymphocytes is associated with a higher incidence …

J Serrano, J Roman, C Herrera, JA Castillejo… - Bone marrow …, 1999 - nature.com
In this study we analysed the incidence and clinical impact of the persistence of host
haemopoiesis (mixed chimaerism, MC) after allogeneic BMT in 35 consecutive patients with …