Pancreatic cancer: Advances and challenges
Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers. Significant
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
efforts have largely defined major genetic factors driving PDAC pathogenesis and …
Evaluation and management of neuroendocrine tumors of the pancreas
AT Scott, JR Howe - Surgical Clinics, 2019 - surgical.theclinics.com
Neuroendocrine tumors (NETs) are a diverse group of neoplasms arising from cells in the
diffuse neuroendocrine system. At least 17 different types of neuroendocrine cells are found …
diffuse neuroendocrine system. At least 17 different types of neuroendocrine cells are found …
ENETS consensus guidelines update for the management of patients with functional pancreatic neuroendocrine tumors and non-functional pancreatic neuroendocrine …
Only advances that occurred from 2011 to 2014 that either strengthen the previous 2011
guidelines [1, 2] or lead to changes or additional guidelines are reviewed here. Advances …
guidelines [1, 2] or lead to changes or additional guidelines are reviewed here. Advances …
Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors
Background & Aims Sporadic pancreatic neuroendocrine tumors (pNETs) are rare and
genetically heterogeneous. Chromosome instability (CIN) has been detected in pNETs from …
genetically heterogeneous. Chromosome instability (CIN) has been detected in pNETs from …
A cross-species analysis in pancreatic neuroendocrine tumors reveals molecular subtypes with distinctive clinical, metastatic, developmental, and metabolic …
Seeking to assess the representative and instructive value of an engineered mouse model
of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled …
of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled …
Neoplasms of the neuroendocrine pancreas: an update in the classification, definition, and molecular genetic advances
JM Guilmette, V Nosé - Advances in anatomic pathology, 2019 - journals.lww.com
This review focuses on discussing the main modifications of the recently published 2017
WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent …
WHO Classification of Neoplasms of the Neuroendocrine Pancreas (panNEN). Recent …
Apelin inhibition prevents resistance and metastasis associated with anti‐angiogenic therapy
I Uribesalgo, D Hoffmann, Y Zhang… - EMBO molecular …, 2019 - embopress.org
Angiogenesis is a hallmark of cancer, promoting growth and metastasis. Anti‐angiogenic
treatment has limited efficacy due to therapy‐induced blood vessel alterations, often …
treatment has limited efficacy due to therapy‐induced blood vessel alterations, often …
A clinicopathologic and molecular update of pancreatic neuroendocrine neoplasms with a focus on the new World Health Organization classification
JM Fang, J Shi - Archives of pathology & laboratory …, 2019 - meridian.allenpress.com
Context.—According to the 2017 World Health Organization classification, pancreatic
neuroendocrine neoplasms (PanNENs) include a new category of pancreatic …
neuroendocrine neoplasms (PanNENs) include a new category of pancreatic …
[HTML][HTML] Update on pancreatic neuroendocrine tumors
LR McKenna, BH Edil - Gland surgery, 2014 - ncbi.nlm.nih.gov
Pancreatic neuroendocrine tumors (pNETs) are relatively rare tumors comprising 1-2% of all
pancreas neoplasms. In the last 10 years our understanding of this disease has increased …
pancreas neoplasms. In the last 10 years our understanding of this disease has increased …
The role of ATRX in the alternative lengthening of telomeres (ALT) phenotype
Telomeres are responsible for protecting chromosome ends in order to prevent the loss of
coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and …
coding DNA. Their maintenance is required for achieving immortality by neoplastic cells and …