Thiazole is one of the most important scaffolds in heterocyclic chemistry and drug design
and discovery. It is widely found in diverse pharmacologically active substances and in …

Cancer is known as one of the main causes of death in the world; and many compounds
have been synthesized to date with potential use in cancer therapy. Thiazole is a versatile …

Epigenetic regulation orchestrates many cellular processes and greatly influences key
disease mechanisms. Histone deacetylase (HDAC) enzymes play a crucial role either as …

Multiple mechanisms for feedback control of cholesterol synthesis converge on the rate-
limiting enzyme in the pathway, 3-hydroxy-3-methylglutaryl coenzyme A reductase. This …

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic
molecules that regulate the expression of more than 150 genes involved in a broad range of …

Protein misfolding leads to the formation of aggregated proteins and protein inclusions,
which are associated with synaptic loss and neuronal death in neurodegenerative diseases …

The environmental, genetic, and/or age-related changes in proteostasis induce
inflammation, oxidative stress, and apoptosis. We quantified the correlation of protein …

Histone deacetylases (HDACs), or lysine deacetylases (KDAC), are epigenetic regulators
that catalyze the removal of acetyl moieties from the tails of lysine residues of histones and …

Background The mutation in the cystic fibrosis transmembrane conductance regulator
(CFTR) gene results in CF. The most common mutation, ΔF508-CFTR, is a temperature …

Cigarette smoke (CS) exposure is known to induce proteostasis imbalance that can initiate
accumulation of ubiquitinated proteins. Therefore, the primary goal of this study was to …