Adaptive laboratory evolution–principles and applications for biotechnology

M Dragosits, D Mattanovich - Microbial cell factories, 2013 - Springer
Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …

Recombinant pharmaceuticals from microbial cells: a 2015 update

L Sanchez-Garcia, L Martín, R Mangues… - Microbial cell …, 2016 - Springer
Diabetes, growth or clotting disorders are among the spectrum of human diseases related to
protein absence or malfunction. Since these pathologies cannot be yet regularly treated by …

Challenges and progress towards industrial recombinant protein production in yeasts: a review

P De Brabander, E Uitterhaegen, T Delmulle… - Biotechnology …, 2023 - Elsevier
Recombinant proteins (RP) are widely used as biopharmaceuticals, industrial enzymes, or
sustainable food source. Yeasts, with their ability to produce complex proteins through a …

Emerging trends in genetic engineering of microalgae for commercial applications

SB Grama, Z Liu, J Li - Marine Drugs, 2022 - mdpi.com
Recently, microalgal biotechnology has received increasing interests in producing valuable,
sustainable and environmentally friendly bioproducts. The development of economically …

Industrial Production of Proteins with Pichia pastorisKomagataella phaffii

GD Barone, A Emmerstorfer-Augustin, A Biundo… - Biomolecules, 2023 - mdpi.com
Since the mid-1960s, methylotrophic yeast Komagataella phaffii (previously described as
Pichia pastoris) has received increasing scientific attention. The interest for the industrial …

[HTML][HTML] Challenges and opportunities for non-antibody scaffold drugs

R Vazquez-Lombardi, TG Phan, C Zimmermann… - Drug discovery today, 2015 - Elsevier
Highlights•Non-antibody scaffold drugs are a promising new class of biologics drugs.•The
first candidate scaffolds are now moving into clinical development and practice.•Challenges …

The potential for microalgae as bioreactors to produce pharmaceuticals

N Yan, C Fan, Y Chen, Z Hu - International journal of molecular sciences, 2016 - mdpi.com
As photosynthetic organisms, microalgae can efficiently convert solar energy into biomass.
Microalgae are currently used as an important source of valuable natural biologically active …

Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses

BA Rasala, SP Mayfield - Photosynthesis research, 2015 - Springer
Recombinant proteins are widely used for industrial, nutritional, and medical applications.
Green microalgae have attracted considerable attention recently as a biomanufacturing …

Pichia Pastoris: Protein Production Host and Model Organism for Biomedical Research

B Gasser, R Prielhofer, H Marx, M Maurer… - Future …, 2013 - Taylor & Francis
Pichia pastoris is the most frequently used yeast system for heterologous protein production
today. The last few years have seen several products based on this platform reach approval …

Microalgae and cyanobacteria as enzyme biofactories

BSAF Brasil, FG de Siqueira, TFC Salum, CM Zanette… - Algal research, 2017 - Elsevier
Microalgae consist of a diverse group that includes prokaryotic cyanobacteria and
eukaryotic photosynthetic microorganisms that inhabit freshwater and marine habitats …