Currently, osteoarthritis (OA) is considered a disease of the entire joint, which is not simply a
process of wear and tear but rather abnormal remodelling and joint failure of an organ. The …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

Osteoarthritis (OA), the most common form of arthritis, is a debilitating and progressive
disease that has become a major cause of disability and impaired quality of life in the …

The discovery of the receptor activator of nuclear factor-kB (RANK)/RANK Ligand (RANKL)/
osteoprotegerin (OPG) pathway contributed to the understanding of how bone formation and …

Introduction Osteoporosis (OP) increases cartilage damage in a combined rabbit model of
OP and osteoarthritis (OA). Accordingly, we assessed whether microstructure impairment at …

Osteoarthritis (OA) is a potentially disabling disease whose progression is dependent on
several risk factors. OA management usually involves the use of non-steroidal anti …

The large variety of biological functions governed by prostaglandin (PG) E2 is mediated by
signaling through four distinct E-type prostanoid (EP) receptors. The availability of mouse …

Betacellulin, a member of the epidermal growth factor (EGF) family, was originally isolated
and identified from the conditioned medium from a murine pancreatic beta-cell carcinoma …

PURPOSE: Impairment of subchondral bone density and quality aggravates cartilage
damage in osteoarthritis (OA). Accordingly, we assessed whether improving microstructure …

Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of
articular cartilage, subchondral bone sclerosis, osteophyte formation, and synovial …