Stable isotope labelling methods in mass spectrometry-based quantitative proteomics

O Chahrour, D Cobice, J Malone - Journal of pharmaceutical and …, 2015 - Elsevier
Mass-spectrometry based proteomics has evolved as a promising technology over the last
decade and is undergoing a dramatic development in a number of different areas, such as; …

Photo-affinity labeling (PAL) in chemical proteomics: a handy tool to investigate protein-protein interactions (PPIs)

DP Murale, SC Hong, MM Haque, JS Lee - Proteome Science, 2016 - Springer
Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that
are crucial for biomedical research and drug discovery. Various techniques have been used …

Omics of blood pressure and hypertension

DK Arnett, SA Claas - Circulation Research, 2018 - Am Heart Assoc
Essential hypertension is a common, complex disorder affecting≤ 1 billion adults globally.
Blood pressure is a highly heritable trait, with≤ 50% of the variation between individuals …

Label-free proteome quantification and evaluation

J Fu, Q Yang, Y Luo, S Zhang, J Tang… - Briefings in …, 2023 - academic.oup.com
The label-free quantification (LFQ) has emerged as an exceptional technique in proteomics
owing to its broad proteome coverage, great dynamic ranges and enhanced analytical …

[HTML][HTML] Omics technologies to understand drug toxicity mechanisms

N Nguyen, D Jennen, J Kleinjans - Drug Discovery Today, 2022 - Elsevier
Highlights•High throughput technologies (HTPs) provide quantitative and multi-dimensional
omics data.•Available HTPs can capture biological alterations in DNA, RNA, protein, and …

Exosomes as emerging biomarker tools in neurodegenerative and neuropsychiatric disorders—a proteomics perspective

B Mathew, MS Mansuri, KR Williams, AC Nairn - Brain Sciences, 2021 - mdpi.com
Exosomes are synthesized and secreted by different cell types and contain proteins, lipids,
metabolites and RNA species that reflect the physiological status of the cell of origin. As …

Comparative proteomics and phosphoproteomics analysis reveal the possible breed difference in yorkshire and duroc boar spermatozoa

Y Xu, Q Han, C Ma, Y Wang, P Zhang, C Li… - Frontiers in Cell and …, 2021 - frontiersin.org
Sperm cells are of unique elongated structure and function, the development of which is
tightly regulated by the existing proteins and the posttranslational modifications (PTM) of …

Toward biotechnology in space: High-throughput instruments for in situ biological research beyond Earth

F Karouia, K Peyvan, A Pohorille - Biotechnology advances, 2017 - Elsevier
Abstract Space biotechnology is a nascent field aimed at applying tools of modern biology to
advance our goals in space exploration. These advances rely on our ability to exploit in situ …

Concepts and strategies of soybean seed proteomics using the shotgun proteomics approach

CW Min, R Gupta, GK Agrawal, R Rakwal… - Expert Review of …, 2019 - Taylor & Francis
Introduction: The last decade has yielded significant developments in the field of proteomics,
especially in mass spectrometry (MS) and data analysis tools. In particular, a shift from gel …

Mechanistic insights into dietary (poly) phenols and vascular dysfunction-related diseases using multi-omics and integrative approaches: Machine learning as a next …

D Milenkovic, T Ruskovska - Molecular aspects of medicine, 2023 - Elsevier
Dietary (poly) phenols have been extensively studied for their vasculoprotective effects and
consequently their role in preventing or delaying onsets of cardiovascular and metabolic …