Results. Potential mechanisms for synergism between viruses and bacteria include: virus
destruction of respiratory epithelium may increase bacterial adhesion; virus-induced …

Influenza virus with resistance to antiviral drugs emerges with increased frequency in
immunocompromised patients and can limit the benefit of M2 and neuraminidase (NA) …

Autophagy is involved in the replication of viruses, especially those that perform RNA
assembly on the surface of cytoplasmic membrane in host cells. However, little is known …

A wide use of inhibitors of influenza virus neuraminidase (NAIs) to control influenza in
humans demands a better understanding of the mechanisms involved in the resistance …

Covering: 2000 to 2011 The imminent threat of influenza pandemics and repeatedly
reported emergence of new drug-resistant influenza virus strains demonstrate the urgent …

Secondary bacterial pneumonia is an important cause of influenza-associated death.
Although antibacterial therapy is standard, antiviral therapy has been ignored because viral …

Influenza virus neuraminidase (NA), a type II transmembrane glycoprotein, possesses
receptor-destroying activity and thereby facilitates virus release from the cell surface. Among …

ABSTRACT The H3N2 influenza A/Fujian/411/02-like virus strains that circulated during the
2003-2004 influenza season caused influenza epidemics. Most of the A/Fujian/411/02 virus …

The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication
and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that …

Influenza virus neuraminidase (NA) is an interesting target of small-molecule antiviral drugs.
We isolated a set of H5N1 NA-specific single-domain antibodies (N1-VHHm) and evaluated …