Background Despite significant advances in molecular characterization and therapeutic
targeting of advanced prostate cancer, it remains the second most common cause of cancer …

In the era of precision medicine, it has been increasingly recognized that individuals with a
certain disease are complex and different from each other. Due to the underestimation of the …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Simple Summary De novo metastatic hormone-sensitive prostate cancer usually has a
dismal prognosis, which has slightly improved in recent years thanks to the introduction of …

Loss of α6β4-dependent hemidesmosomal adhesions has been observed during prostate
cancer progression. However, the significance and underlying mechanisms by which …

Simple Summary Accumulating studies have highlighted the critical roles of microRNAs in
tumorigenesis and cancer treatment responses. Here, we systematically review the scientific …

Metformin is the first-line oral antidiabetic drug that shows multiple pleiotropic effects of anti-
inflamation, anti-cancer, anti-aging, anti-microbia, anti-atherosclerosis, and immune …

The initiation of prostate cancer has been long associated with DNA copy-number
alterations, the loss of specific chromosomal regions and gene fusions, and driver mutations …

Simple Summary Intraductal carcinoma of the prostate (IDC-P) is a neoplastic proliferation
within the prostatic ducts with a retained basal cell layer that exceeds the usual extent of …

Cancer vaccines drive the activation and proliferation of tumor-reactive immune cells,
thereby eliciting tumor-specific immunity that kills tumor cells. Accordingly, they possess …