The primary inhibitory neurotransmitter γ-aminobutyric acid (GABA) has a prominent role in
regulating neural development and function, with disruption to GABAergic signalling linked …

Alzheimer's disease (AD) is a common chronic neurodegenerative disease characterized by
cognitive learning and memory impairments, however, current treatments only provide …

BAZ1B is a ubiquitously expressed nuclear protein with roles in chromatin remodeling, DNA
replication and repair, and transcription. Reduced BAZ1B expression disrupts neuronal and …

Copy number variations at 7q11. 23 cause neurodevelopmental disorders with shared and
opposite manifestations. Deletion causes Williams-Beuren syndrome featuring …

Copy number variation (CNV) at 7q11. 23 causes distinct disorders with both contrasting
and overlapping phenotypic features of some but not all of the genes encompassed by the …

DLX5 and DLX6 are two closely related transcription factors involved in brain development
and in GABAergic differentiation. The DLX5/6 locus is regulated by FoxP2, a gene involved …

Drug exposure during adolescence, when the “reward” circuitry of the brain is developing,
can permanently impact reward-related behavior into adulthood. Epidemiological studies …

Inhibition of lysine-specific demethylase 1 (LSD1) enzyme activity is a promising approach
to treat diseases associated with epigenetic dysregulation, such as neurodevelopmental …

Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes
encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) …

Mucopolysaccharidoses (MPS) are a group of diseases caused by mutations in genes
encoding lysosomal enzymes that catalyze reactions of glycosaminoglycan (GAG) …