An agonist that acts through a single receptor can activate numerous signaling pathways.
Recent studies have suggested that different ligands can differentially activate these …

Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …

Sex hormones and white (and grey) matter in the limbic system, cortex and other brain
regions undergo changes during adolescence. Some of these changes include ongoing …

Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be
fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival …

Background & Objective: Cannabis is one of the earliest cultivated plants. Cannabis of
industrial utility and culinary value is generally termed as hemp. Conversely, cannabis that is …

Acute Respiratory Distress Syndrome (ARDS) causes up to 40% mortality in humans and is
difficult to treat. ARDS is also one of the major triggers of mortality associated with …

BACKGROUND: Cannabinoids present neurotoxic and neuroprotective properties in in vitro
studies, inconsistent alterations in human neuroimaging studies, neuropsychological …

Numerous investigations have recently demonstrated the important roles of the
endocannabinoid system in the gastrointestinal (GI) tract under physiological and …

The c-Jun N-terminal kinases (JNKs) are important regulators of physiological and
pathological processes in the central and peripheral nervous system. In general, JNKs are …

Toll-like receptors (TLRs) are sensors of pathogen-associated molecules that trigger
inflammatory signalling in innate immune cells including macrophages. All TLRs, with the …