TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
Mechanical stretch: physiological and pathological implications for human vascular endothelial cells
Vascular endothelial cells are subjected to hemodynamic forces such as mechanical stretch
due to the pulsatile nature of blood flow. Mechanical stretch of different intensities is …
due to the pulsatile nature of blood flow. Mechanical stretch of different intensities is …
TRPs and pain
Y Dai - Seminars in Immunopathology, 2016 - Springer
Nociception is the process of transmission of painful signals by nociceptors in the primary
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …
afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are …
TRPV4 channels mediate cardiac fibroblast differentiation by integrating mechanical and soluble signals
RK Adapala, RJ Thoppil, DJ Luther, S Paruchuri… - Journal of molecular and …, 2013 - Elsevier
The phenotypic switch underlying the differentiation of cardiac fibroblasts into
hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial …
hypersecretory myofibroblasts is critical for cardiac remodeling following myocardial …
AKAP150-dependent cooperative TRPV4 channel gating is central to endothelium-dependent vasodilation and is disrupted in hypertension
Endothelial cell dysfunction, characterized by a diminished response to endothelial cell–
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
dependent vasodilators, is a hallmark of hypertension. TRPV4 channels play a major role in …
TRPV4 deletion protects heart from myocardial infarction-induced adverse remodeling via modulation of cardiac fibroblast differentiation
Cardiac fibrosis caused by adverse cardiac remodeling following myocardial infarction can
eventually lead to heart failure. Although the role of soluble factors such as TGF-β is well …
eventually lead to heart failure. Although the role of soluble factors such as TGF-β is well …
Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy
RK Adapala, RJ Thoppil, K Ghosh, HC Cappelli… - Oncogene, 2016 - nature.com
Tumor vessels are characterized by abnormal morphology and hyperpermeability that
together cause inefficient delivery of chemotherapeutic agents. Although vascular …
together cause inefficient delivery of chemotherapeutic agents. Although vascular …
Trafficking of thermoTRP channels
C Ferrandiz-Huertas, S Mathivanan, CJ Wolf, I Devesa… - Membranes, 2014 - mdpi.com
ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential
(TRP) channels that are activated by changes in the environmental temperature, from …
(TRP) channels that are activated by changes in the environmental temperature, from …
Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling
DP Poole, S Amadesi, NA Veldhuis… - Journal of biological …, 2013 - ASBMB
G protein-coupled receptors of nociceptive neurons can sensitize transient receptor potential
(TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …
(TRP) ion channels, which amplify neurogenic inflammation and pain. Protease-activated …
Modulation of the TRPV4 ion channel as a therapeutic target for disease
Abstract Transient Receptor Potential Vanilloid 4 (TRPV4) is a broadly expressed,
polymodally gated ion channel that plays an important role in many physiological and …
polymodally gated ion channel that plays an important role in many physiological and …