[HTML][HTML] VEGF/VEGFR-targeted therapy and immunotherapy in non-small cell lung cancer: targeting the tumor microenvironment

Y Zhao, S Guo, J Deng, J Shen, F Du… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Non-small cell lung cancer (NSCLC) is the leading cause of death by cancer worldwide.
Despite developments in therapeutic approaches for the past few decades, the 5-year …

Mechanistic pathogenesis of endothelial dysfunction in diabetic nephropathy and retinopathy

J Yang, Z Liu - Frontiers in endocrinology, 2022 - frontiersin.org
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are microvascular complications of
diabetes. Microvascular endothelial cells are thought to be the major targets of …

Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

[HTML][HTML] A narrative review of tumor-associated macrophages in lung cancer: regulation of macrophage polarization and therapeutic implications

SS Sedighzadeh, AP Khoshbin, S Razi… - … lung cancer research, 2021 - ncbi.nlm.nih.gov
Lung cancer is the deadliest malignancy worldwide. An inflammatory microenvironment is a
key factor contributing to lung tumor progression. Tumor-Associated Macrophages (TAMs) …

Molecular structure, spectroscopic (FT-IR, FT-Raman, NMR), HOMO-LUMO, chemical reactivity, AIM, ELF, LOL and Molecular docking studies on 1-Benzyl-4-(N-Boc …

S Janani, H Rajagopal, S Muthu, S Aayisha… - Journal of Molecular …, 2021 - Elsevier
In the present study, 1-Benzyl-4-(N-Boc-amino) piperidine was characterized by
spectroscopic investigations employing FT-IR, FT-Raman, UV-Vis and NMR (13 C, 1 H) …

Melatonin restricts the viability and angiogenesis of vascular endothelial cells by suppressing HIF-1α/ROS/VEGF

J Cheng, HL Yang, CJ Gu, YK Liu… - International …, 2019 - spandidos-publications.com
Angiogenesis is an essential process involved in various physiological, including
placentation, and pathological, including cancer and endometriosis, processes. Melatonin …

[HTML][HTML] VEGF and FGF-2: Promising targets for the treatment of respiratory disorders

AP Laddha, YA Kulkarni - Respiratory medicine, 2019 - Elsevier
The endothelial cells play a crucial role in the progression of angiogenesis, which causes
cell re-modulation, proliferation, adhesion, migration, invasion and survival. Angiogenic …

LINC00173. v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression

J Chen, A Liu, Z Wang, B Wang, X Chai, W Lu, T Cao… - Molecular cancer, 2020 - Springer
Background Anti-angiogenic therapy represents a promising strategy for non-small-cell lung
cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to …

Current status of immunotherapy for non-small cell lung cancer

T Yang, Y Xiong, Y Zeng, Y Wang, J Zeng… - Frontiers in …, 2022 - frontiersin.org
Nowadays, lung cancer is still the deadliest oncological disease in the world. Among them,
non-small cell lung cancer (NSCLC) accounts for 80%∼ 85% of all lung cancers, and its 5 …

Advances in Stigmasterol on its anti-tumor effect and mechanism of action

X Zhang, J Wang, L Zhu, X Wang, F Meng, L Xia… - Frontiers in …, 2022 - frontiersin.org
Stigmasterol is a phytosterol derived from multiple herbaceous plants such as herbs,
soybean and tobacco, and it has received much attention for its various pharmacological …