Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

Non-coding RNAs regulating mitochondrial function in cardiovascular diseases

X Ao, W Ding, X Li, Q Xu, X Chen, X Zhou… - Journal of Molecular …, 2023 - Springer
Cardiovascular disease (CVD) is the leading cause of disease-related death worldwide and
a significant obstacle to improving patients' health and lives. Mitochondria are core …

Fasting: from physiology to pathology

D Tang, Q Tang, W Huang, Y Zhang, Y Tian… - Advanced …, 2023 - Wiley Online Library
Overnutrition is a risk factor for various human diseases, including neurodegenerative
diseases, metabolic disorders, and cancers. Therefore, targeting overnutrition represents a …

Comprehensive overview of microRNA function in rheumatoid arthritis

X Peng, Q Wang, W Li, G Ge, J Peng, Y Xu, H Yang… - Bone Research, 2023 - nature.com
MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have
emerged as vital epigenetic regulators of both pathological and physiological processes in …

The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications

Z Mao, B Wang, T Zhang, B Cui - Cell Death & Disease, 2023 - nature.com
Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily
attributed to the persistent infection of high-risk Human papillomavirus (HPV). Despite …

Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling

S Tang, X Nie, J Ruan, Y Cao, J Kang, C Ding - Cell Death & Disease, 2022 - nature.com
Inflammatory cytokines-induced activation of the nuclear factor κB (NF-κB) pathway plays a
critical role in the pathogenesis of osteoarthritis (OA). Circular RNA (circRNA) has been …

[HTML][HTML] The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis

J Yang, Z Li, L Wang, X Yun, Y Zeng, JPL Ng… - Pharmacological …, 2022 - Elsevier
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which is associated
with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive …

Engineering of MSC-derived exosomes: a promising cell-free therapy for osteoarthritis

J Cheng, Y Sun, Y Ma, Y Ao, X Hu, Q Meng - Membranes, 2022 - mdpi.com
Osteoarthritis (OA) is characterized by progressive cartilage degeneration with increasing
prevalence and unsatisfactory treatment efficacy. Exosomes derived from mesenchymal …

The potential regulatory role of the lncRNA-miRNA-mRNA axis in teleost fish

Z Zhou, C Leng, Z Wang, L Long, Y Lv, Z Gao… - Frontiers in …, 2023 - frontiersin.org
Research over the past two decades has confirmed that noncoding RNAs (ncRNAs), which
are abundant in cells from yeast to vertebrates, are no longer “junk” transcripts but functional …

Exploring the feasibility of circulating miRNAs as diagnostic and prognostic biomarkers in osteoarthritis: Challenges and opportunities

K Felekkis, M Pieri, C Papaneophytou - International Journal of Molecular …, 2023 - mdpi.com
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive
cartilage degradation and joint inflammation. As the most common aging-related joint …