Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
Abstract KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a
number of gene promoters and regulating their transcription. KLF5 is expressed during …
number of gene promoters and regulating their transcription. KLF5 is expressed during …
The translation of Helicobacter pylori basic research to patient care
In 1984, Barry Marshall and Robin Warren proposed a role for bacterial infections in the
pathogenesis of gastroduodenal disease, which triggered an avalanche of research …
pathogenesis of gastroduodenal disease, which triggered an avalanche of research …
Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection
K Guillemin, NR Salama… - Proceedings of the …, 2002 - National Acad Sciences
Helicobacter pylori infects over half the world's population and causes a wide range of
diseases, including gastritis, peptic ulcer, and two forms of gastric cancer. H. pylori infection …
diseases, including gastritis, peptic ulcer, and two forms of gastric cancer. H. pylori infection …
[HTML][HTML] Association between the pig genome and its gut microbiota composition
D Crespo-Piazuelo, L Migura-Garcia, J Estellé… - Scientific reports, 2019 - nature.com
The gut microbiota has been evolving with its host along the time creating a symbiotic
relationship. In this study, we assess the role of the host genome in the modulation of the …
relationship. In this study, we assess the role of the host genome in the modulation of the …
[HTML][HTML] RHOA in gastric cancer: functional roles and therapeutic potential
S Nam, JH Kim, DH Lee - Frontiers in genetics, 2019 - frontiersin.org
The well-known signal mediator and small GTPase family member, RHOA, has now been
associated with the progression of specific malignancies. In this review, we appraise the …
associated with the progression of specific malignancies. In this review, we appraise the …
[HTML][HTML] NET1-mediated RhoA activation facilitates lysophosphatidic acid-induced cell migration and invasion in gastric cancer
The most lethal aspects of gastric adenocarcinoma (GA) are its invasive and metastatic
properties. This aggressive phenotype remains poorly understood. We have recently …
properties. This aggressive phenotype remains poorly understood. We have recently …
Screening of gene expression profiles in gastric epithelial cells induced by Helicobacter pylori using microarray analysis
AR Sepulveda, H Tao, E Carloni… - Alimentary …, 2002 - Wiley Online Library
Background: H. pylori infection is a major risk factor in gastric cancer development. The
availability of cDNA microarrays creates the unprecedented opportunity to examine …
availability of cDNA microarrays creates the unprecedented opportunity to examine …
Inflammatory gene profiles in gastric mucosa during Helicobacter pylori infection in humans
S Wen, CP Felley, H Bouzourene… - The Journal of …, 2004 - journals.aai.org
Helicobacter pylori infection is associated with an inflammatory response in the gastric
mucosa, ultimately leading to cellular hyperproliferation and malignant transformation …
mucosa, ultimately leading to cellular hyperproliferation and malignant transformation …
The immediate early gene Ier2 promotes tumor cell motility and metastasis, and predicts poor survival of colorectal cancer patients
A Neeb, S Wallbaum, N Novac, S Dukovic-Schulze… - Oncogene, 2012 - nature.com
Here, we report unbiased screens for genes expressed in metastatic tumor cells that are
associated with cell motility. These screens identified Ier2, an immediate early gene of …
associated with cell motility. These screens identified Ier2, an immediate early gene of …
Global analysis of the human gastric epithelial transcriptome altered by Helicobacter pylori eradication in vivo
MB Resnick, E Sabo, PA Meitner, SS Kim, Y Cho… - Gut, 2006 - gut.bmj.com
Objective: The transcriptional profile of gastric epithelial cell lines cocultured with
Helicobacter pylori and the global gene expression of whole gastric mucosa has been …
Helicobacter pylori and the global gene expression of whole gastric mucosa has been …