Background Schizophrenia is a complex and heterogeneous disorder involving multiple
regions and types of cells in the brain. Despite rapid progress made by genome-wide …

The role of glia in amyotrophic lateral sclerosis (ALS) is undeniable. Their disease-related
activity has been extensively studied in the spinal cord, but only partly in the brain. We …

Some individuals show a discrepancy between cognition and the amount of
neuropathological changes characteristic for Alzheimer's disease (AD). This phenomenon …

Background Microglia, the brain's resident immune cells, play vital roles in brain
development, and disorders like Alzheimer's disease (AD). Human iPSC-derived microglia …

The complex pathobiology of late-onset Alzheimer's disease (AD) poses significant
challenges to therapeutic and preventative interventions. Despite these difficulties …

Summary Alzheimer's disease (AD), the leading cause of dementia, affects millions of
people worldwide. With no disease-modifying medication currently available, the human toll …

Most expression quantitative trait loci (eQTL) studies to date have been performed in
heterogeneous brain tissues as opposed to specific cell types. To investigate the genetics of …

The brain is the most complex organ in the human body and, as such, its study entails great
challenges (methodological, theoretical, etc.). Nonetheless, there is a remarkable amount of …

Previously, we found that amyloid-beta (Aβ) competitively inhibits the kinesin motor protein
KIF11 (Kinesin-5/Eg5), leading to defects in the microtubule network and in neurotransmitter …

Human microglia play a pivotal role in neurological diseases, but few targeted therapies that
directly modulate microglial state or function exist due to an incomplete understanding of …