A pharmacological update of ellagic acid

JL Ríos, RM Giner, M Marín, MC Recio - Planta medica, 2018 - thieme-connect.com
Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is
present either in free form or as part of more complex molecules (ellagitannins), which can …

[HTML][HTML] Ellagic acid and its anti-aging effects on central nervous system

H Zhu, Y Yan, Y Jiang, X Meng - International journal of molecular …, 2022 - mdpi.com
Aging is an unavoidable biological process that leads to the decline of human function and
the reduction in people's quality of life. Demand for anti-aging medicines has become very …

Neuroprotective effects of Ellagic acid in Alzheimer's disease: focus on underlying molecular mechanisms of therapeutic potential

N Javaid, MA Shah, A Rasul… - Current …, 2021 - ingentaconnect.com
Neurodegeneration is a multifactorial process involved the different cytotoxic pathways that
lead to neuronal cell death. Alzheimer's disease (AD) is a persistent neurodegenerative …

Metformin accelerates myelin recovery and ameliorates behavioral deficits in the animal model of multiple sclerosis via adjustment of AMPK/Nrf2/mTOR signaling and …

N Sanadgol, M Barati, F Houshmand, S Hassani… - Pharmacological …, 2020 - Springer
Background Multiple sclerosis (MS) is a devastating autoimmune disorder characterized by
oligodendrocytes (OLGs) loss and demyelination. In this study, we have examined the …

Mesenchymal stem cells ameliorate cuprizone-induced demyelination by targeting oxidative stress and mitochondrial dysfunction

E Shiri, P Pasbakhsh, M Borhani‑Haghighi… - Cellular and molecular …, 2021 - Springer
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system. The main causes of MS disease progression, demyelination, and tissue damage are …

[HTML][HTML] Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis …

N Sanadgol, F Golab, Z Tashakkor, N Taki… - Pharmaceutical …, 2017 - pmc.ncbi.nlm.nih.gov
Context: Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities.
However, the efficacy of EA has not been examined in neuropathologic conditions …

Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor …

F Houshmand, M Barati, F Golab… - DARU Journal of …, 2019 - Springer
Abstract Purpose Oligodendrocytes (OLGs) damage and myelin distraction is considered as
a critical step in many neurological disorders especially multiple sclerosis (MS). Cuprizone …

Acetyl-l-Carnitine Attenuates Arsenic-Induced Oxidative Stress and Hippocampal Mitochondrial Dysfunction

H Keshavarz-Bahaghighat, MR Sepand… - Biological trace element …, 2018 - Springer
Augmentation of mitochondrial oxidative stress through activating a series of deadly events
has implicated as the main culprit of arsenic toxicity and therapeutic approaches based on …

Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis

Z Kiasalari, S Afshin-Majd… - Journal of Chemical …, 2021 - Elsevier
Multiple sclerosis (MS) is presented as the most common autoimmune and demyelinating
neurological disorder with incapacitating complications and with no definite therapy. Most …

The effect of ellagic acid on spinal cord and sciatica function in a mice model of multiple sclerosis

F Khodaei, MJ Khoshnoud, S Heidaryfar… - … of Biochemical and …, 2020 - Wiley Online Library
Multiple sclerosis (MS) is a well‐known neurodegenerative disorder, causing toxicity in
different organs, such as spinal cord tissue. The goal of this study was to investigate the …