CD247, which is also known as CD3ζ, CD3H, CD3Q, CD3Z, IMD25, T3Z and TCRZ,
encodes CD3ζ protein, which is expressed primarily in natural killer (NK) and T cells. Since …

Adaptation of glioblastoma to caloric restriction induces compensatory changes in tumor
metabolism that are incompletely known. Here we show that in human glioblastoma cells …

The present study investigated the expression and potential influence of SHC SH2 domain‑
binding protein 1 (SHCBP1) in gastric cancer (GC) cells. SHCBP1 is closely related to cell …

Background The immunosuppressive tumor microenvironment (TME) of colorectal cancer
(CRC) is a major hurdle for immune checkpoint inhibitor-based therapies. Hence …

Multiple sclerosis is an autoimmune disease caused by autoreactive immune cell infiltration
into the central nervous system leading to inflammation, demyelination, and neuronal loss …

Rai prevents lupus nephritis by impairing the development and expansion of both
proinflammatory Th17 and Th1 cells. Rai, a Shc adapter family member, acts as a negative …

Th17 cells have been casually associated to the pathogenesis of autoimmune disease. We
have previously demonstrated that Rai/ShcC, a member of the Shc family of adaptor …

To date, most studies of Shc family of signaling adaptor proteins have been focused on the
near-ubiquitously expressed ShcA, indicating its relevance to age-related diseases and …

Proteins of the Src homology and collagen (Shc) family are typically involved in signal
transduction events involving Ras/MAPK and PI3K/Akt pathways. In the nervous system …

Hypoxia occurs in physiological and pathological conditions. T cells experience hypoxia in
pathological and physiological conditions as well as in lymphoid organs. Indeed, hypoxia …