[HTML][HTML] Quinones as neuroprotective agents
Á Cores, N Carmona-Zafra, J Clerigué, M Villacampa… - Antioxidants, 2023 - mdpi.com
Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …
Targeting epigenetics: a novel promise for Alzheimer's disease treatment
D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing Research Reviews, 2023 - Elsevier
So far, the search for a cure for Alzheimer Disease (AD) has been unsuccessful. The only
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
approved drugs attenuate some symptoms, but do not halt the progress of this disease …
[PDF][PDF] Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses.
Alzheimer's disease (AD) is a prevalent neurodegenerative disease characterized by both
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
amnestic and non-amnestic clinical manifestations. It accounts for approximately 60-70% of …
[HTML][HTML] Microorganism-derived molecules as enzyme inhibitors to target Alzheimer's diseases pathways
Alzheimer's disease (AD) is the most common form of dementia. It increases the risk of other
serious diseases and causes a huge impact on individuals, families, and socioeconomics …
serious diseases and causes a huge impact on individuals, families, and socioeconomics …
Discovery of triazole-bridged aryl adamantane analogs as an intriguing class of multifunctional agents for treatment of Alzheimer's disease
Alzheimer's disease (AD) is a progressive brain disorder associated with slow loss of brain
functions leading to memory failure and modest changes in behavior. The multifactorial …
functions leading to memory failure and modest changes in behavior. The multifactorial …
Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer's disease mice
Efficient multi-targeted intervention of complex pathogenic factors may hold promises for
Alzheimer's disease (AD) treatment due to the continuous failure of single-targeted therapy …
Alzheimer's disease (AD) treatment due to the continuous failure of single-targeted therapy …
[HTML][HTML] Transcriptomic analysis of glutamate-induced HT22 neurotoxicity as a model for screening anti-Alzheimer's drugs
A Prasansuklab, S Sukjamnong, A Theerasri, VW Hu… - Scientific reports, 2023 - nature.com
Glutamate-induced neurotoxicity in the HT22 mouse hippocampal neuronal cell line has
been recognized as a valuable cell model for the study of neurotoxicity associated with …
been recognized as a valuable cell model for the study of neurotoxicity associated with …
[HTML][HTML] Hippocampal delivery of neurotrophic factor-α1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's disease …
Alzheimer's Disease (AD) is a prevalent neurodegenerative disease characterized by tau
hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents …
hyperphosphorylation, Aβ1-42 aggregation and cognitive dysfunction. Therapeutic agents …
[HTML][HTML] Anti-amyloid therapies for Alzheimer's disease and the amyloid cascade hypothesis
E Fedele - International journal of molecular sciences, 2023 - mdpi.com
Over the past 30 years, the majority of (pre) clinical efforts to find an effective therapy for
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …
Alzheimer's disease (AD) focused on clearing the β-amyloid peptide (Aβ) from the brain …
[HTML][HTML] Therapeutic inhalation of hydrogen gas for alzheimer's disease patients and subsequent long-term follow-up as a disease-modifying treatment: An open label …
H Ono, Y Nishijima, S Ohta - Pharmaceuticals, 2023 - mdpi.com
(1) Background: Alzheimer's disease (AD) is a progressive and fatal neurodegenerative
disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as …
disorder. Hydrogen gas (H2) is a therapeutic medical gas with multiple functions such as …