[HTML][HTML] Antivirals for COVID-19: a critical review

A Frediansyah, R Tiwari, K Sharun, K Dhama… - … and global health, 2021 - Elsevier
No specific drugs have been approved for coronavirus disease 2019 (COVID-19) to date as
the development of antivirals usually requires time. Therefore, assessment and use of …

Obesity as a risk factor for COVID-19: an overview

RW Alberca, LM Oliveira, ACCC Branco… - Critical reviews in …, 2021 - Taylor & Francis
The current coronavirus disease-2019 (COVID-19) pandemic presents a huge challenge for
health-care systems worldwide. Many different risk factors are associated with disease …

[HTML][HTML] Protein kinases: drug targets for immunological disorders

L Castelo-Soccio, H Kim, M Gadina… - Nature Reviews …, 2023 - nature.com
Protein kinases play a major role in cellular activation processes, including signal
transduction by diverse immunoreceptors. Given their roles in cell growth and death and in …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

X Zhang, Y Zhang, W Qiao, J Zhang, Z Qi - International …, 2020 - Elsevier
In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly …

Use of baricitinib in patients with moderate to severe coronavirus disease 2019

BK Titanji, MM Farley, A Mehta… - Clinical Infectious …, 2021 - academic.oup.com
Hyperinflammation is associated with increased mortality in coronavirus disease 2019
(COVID-19). In this retrospective, uncontrolled patient cohort with moderate-severe COVID …

Liver injury is associated with severe coronavirus disease 2019 (COVID‐19) infection: a systematic review and meta‐analysis of retrospective studies

M Parohan, S Yaghoubi, A Seraji - Hepatology Research, 2020 - Wiley Online Library
The coronavirus disease 2019 (COVID‐19) outbreak is a major threat to human beings.
Lung injury has been reported as the major outcome of COVID‐19 infection. However, liver …

[PDF][PDF] An update on COVID-19: SARS-CoV-2 variants, antiviral drugs, and vaccines

VE Hillary, SA Ceasar - Heliyon, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious and
pathogenic virus that first appeared in late December 2019. This SARS-CoV-2 causes an …

A compendium answering 150 questions on COVID‐19 and SARS‐CoV‐2

C Riggioni, P Comberiati, M Giovannini, I Agache… - Allergy, 2020 - Wiley Online Library
Abstract In December 2019, China reported the first cases of the coronavirus disease 2019
(COVID‐19). This disease, caused by the severe acute respiratory syndrome–related …

COVID-19: Review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking

G Magro - Virus research, 2020 - Elsevier
SARS-CoV-2 is the agent responsible for COVID-19. The infection can be dived into three
phases: mild infection, the pulmonary phase and the inflammatory phase. Treatment options …