Nearly half of the patients with newly diagnosed glioblastomas are aged≥ 65 years.
Unfortunately, these elderly patients with glioblastoma (GBM-e) demonstrate detrimental …

Background The goal was to determine whether the addition of temozolomide (TMZ) to the
standard treatment of high-dose methotrexate (HD-MTX) and whole-brain radiotherapy …

Background: The most frequent and most aggressive primary brain tumor, glioblastoma
(GBM) has an extremely poor prognosis. Several studies have shown the involvement of sex …

Background There is lack of consensus regarding optimal adjuvant therapy in elderly
glioblastoma (GBM). We have been treating elderly (≥ 60 years) GBM patients with …

Optimizing the management of elderly patients with glioblastoma is an ongoing task in neuro-
oncology. The number of patients with this tumor type is gradually increasing with the aging …

Background Glioblastoma is the most aggressive primary brain cancer with a poor
prognosis. Despite numerous studies in the past 17 years, effective treatment options for …

Background: Radiotherapy combined with temozolomide chemotherapy (STUPP regimen) is
the standard treatment regimen for newly diagnosed glioblastoma (GBM). It is considered …

Introduction: Gliomas are primary tumors of the central nervous system with an aggressive
pattern of progression with a poor prognosis in terms of survival and quality of life. The …

Malignant glioma can be divided into grade III (Gr. III) and grade IV (Gr. IV). Gr. III glioma
patients have significantly better overall survival (OS) than those with Gr. IV glioma, also …

Background. Perilesional edema in patients affected by brain mass lesions is a frequently
encountered phenomenon that strongly contributes to neurological signs and symptoms. In …