[HTML][HTML] Human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate the repair of spinal cord injury via the miR-29b-3p/PTEN/Akt/mTOR axis

X Xiao, W Li, D Rong, Z Xu, Z Zhang, H Ye, L Xie… - Cell Death …, 2021 - nature.com
Spinal cord injury (SCI) is a salient traumatic disease that often leads to permanent
disability, and motor and sensory impairments. Human umbilical cord mesenchymal stem …

[HTML][HTML] The effect of Matrigel as scaffold material for neural stem cell transplantation for treating spinal cord injury

J Wang, R Chu, N Ni, G Nan - Scientific reports, 2020 - nature.com
Traumatic injury to the spinal cord causes permanent loss of function and major personal,
social, and economic problems. Cell-based delivery strategies is a promising approach for …

Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy

B Xu, Z Zhou, J Fang, J Wang, K Tao, J Liu… - Free Radical Biology and …, 2023 - Elsevier
Although spinal cord injury (SCI) represents a primary etiology of disability, currently, there
are exist limited viable therapies modalities. Acquiring comprehension of the diverse …

Nerve growth factor delivery by ultrasound-mediated nanobubble destruction as a treatment for acute spinal cord injury in rats

Z Song, Z Wang, J Shen, S Xu, Z Hu - International journal of …, 2017 - Taylor & Francis
Background Spinal cord injuries (SCIs) can cause severe disability or death. Treatment
options include surgical intervention, drug therapy, and stem cell transplantation. However …

A novel hydrogel-based combination therapy for effective neuroregeneration after spinal cord injury

Q Wang, X Dong, H Zhang, P Li, X Lu, M Wu… - Chemical Engineering …, 2021 - Elsevier
Spinal cord injury (SCI) remains a challenging clinical problem worldwide. Combination
therapy is a promising therapeutic strategy for SCI. Recent investigations have reported that …

[HTML][HTML] Inhibition of autophagy and RIP1/RIP3/MLKL-mediated necroptosis by edaravone attenuates blood spinal cord barrier disruption following spinal cord injury

B Xu, J Fang, J Wang, X Jin, S Liu, K Song… - Biomedicine & …, 2023 - Elsevier
The disruption of the blood spinal cord barrier (BSCB) after spinal cord injury (SCI) can
trigger secondary tissue damage. Edaravone is likely to protect the BSCB as a free radical …

Curcumin-primed umbilical cord mesenchymal stem cells-derived extracellular vesicles improve motor functional recovery of mice with complete spinal cord injury by …

W Xiong, H Tian, Z Li, Z Peng, Y Wang - Neurochemical Research, 2023 - Springer
Background Transplantation of extracellular vesicles (EVs) from stem cells is a feasible
scheme for traumatic spinal cord injury (SCI). However, there is no relevant report about …

Role of melatonin in the dynamics of acute spinal cord injury in rats

J Bi, J Shen, C Chen, Z Li, H Tan… - Journal of Cellular and …, 2021 - Wiley Online Library
Melatonin is well‐documented to have the ability of reducing nerve inflammation and
scavenging free radicals. However, the therapeutic effect of melatonin on spinal cord injury …

HBO-PC promotes locomotor recovery by reducing apoptosis and inflammation in SCI rats: the role of the mTOR signaling pathway

H Chen, G Xu, Y Wu, X Wang, F Wang… - Cellular and Molecular …, 2021 - Springer
Abstract Hyperbaric oxygen preconditioning (HBO-PC) has beneficial effects on the
promotion of locomotor recovery by reducing apoptosis and inflammation after traumatic …

[HTML][HTML] Myelotomy promotes locomotor recovery in rats subjected to spinal cord injury: a meta-analysis of six randomized controlled trials

C Qin, WH Zhang, DG Yang, ML Yang… - Neural Regeneration …, 2018 - journals.lww.com
OBJECTIVE: To investigate the effects of myelotomy on locomotor recovery in rats subjected
to spinal cord injury. DATA SOURCES: Electronic databases including PubMed, Science …