Mechanobiology is a rapidly growing research area focused on how mechanical forces and
properties influence biological systems at the cell, molecular, and tissue level, and how …

A single gene mutation can cause a number of human diseases that affect the quality of life.
Until the development of clustered regularly interspaced short palindromic repeats …

Aberrations in nuclear size and shape are commonly used to identify cancerous tissue.
However, it remains unclear whether the disturbed nuclear structure directly contributes to …

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion,
intravasation, circulation, arrest/adhesion and extravasation require specific mechanical …

The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as pan-tumor
oncogenic drivers has led to new personalized therapies in oncology. Recent studies …

Abstract Mutations in the Prominin‐1 (Prom1) gene disrupt photoreceptor disk
morphogenesis, leading to macular dystrophies. We have shown that human retinal pigment …

In advanced metastatic cancers with reduced patient survival and poor prognosis,
expression of vimentin, a type III intermediate filament protein is frequently observed …

Background Inhibition of mutant KRAS challenged cancer research for decades. Recently,
allele-specific inhibitors were approved for the treatment of KRAS-G12C mutant lung cancer …

Deleterious, mostly de novo, mutations in the lamin A (LMNA) gene cause spatio‐functional
nuclear abnormalities that result in several laminopathy‐associated progeroid conditions. In …

Lamin A, a main constituent of the nuclear lamina, is involved in mechanosignaling and cell
migration through dynamic interactions with the LINC complex, formed by the nuclear …