A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

[HTML][HTML] lifex: A flexible, high performance library for the numerical solution of complex finite element problems

PC Africa - SoftwareX, 2022 - Elsevier
Numerical simulations are ubiquitous in mathematics and computational science. Several
industrial and clinical applications entail modeling complex multiphysics systems that evolve …

[HTML][HTML] Patient-specific modeling of blood flow in the coronary arteries

CA Taylor, K Petersen, N Xiao, M Sinclair, Y Bai… - Computer Methods in …, 2023 - Elsevier
Patient-specific models of blood flow in the coronary arteries have entered clinical practice
worldwide to aid in the diagnosis and management of heart disease. This technology …

lifex-cfd: An open-source computational fluid dynamics solver for cardiovascular applications

PC Africa, I Fumagalli, M Bucelli, A Zingaro… - Computer Physics …, 2024 - Elsevier
Computational fluid dynamics (CFD) is an important tool for the simulation of the
cardiovascular function and dysfunction. Due to the complexity of the anatomy, the …

Impact of atrial fibrillation on left atrium haemodynamics: A computational fluid dynamics study

M Corti, A Zingaro, AM Quarteroni - Computers in Biology and Medicine, 2022 - Elsevier
We analyse the haemodynamics of the left atrium, highlighting differences between healthy
individuals and patients affected by atrial fibrillation. The computational study is based on …

[HTML][HTML] Reconstructing relaxed configurations in elastic bodies: Mathematical formulations and numerical methods for cardiac modeling

NA Barnafi, F Regazzoni, D Riccobelli - Computer Methods in Applied …, 2024 - Elsevier
Modeling the behavior of biological tissues and organs often necessitates the knowledge of
their shape in the absence of external loads. However, when their geometry is acquired in …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

[PDF][PDF] svFSI: a multiphysics package for integrated cardiac modeling

C Zhu, V Vedula, D Parker, N Wilson… - Journal of Open …, 2022 - joss.theoj.org
Heart disease is the number one cause of death in the US (Xu et al., 2020). Many efforts
have been devoted to studying its progression, diagnosis, and treatment. During the past …

lifex-fiber: an open tool for myofibers generation in cardiac computational models

PC Africa, R Piersanti, M Fedele, L Dede'… - BMC …, 2023 - Springer
Background Modeling the whole cardiac function involves the solution of several complex
multi-physics and multi-scale models that are highly computationally demanding, which call …

lifex-ep: a robust and efficient software for cardiac electrophysiology simulations

PC Africa, R Piersanti, F Regazzoni, M Bucelli… - BMC …, 2023 - Springer
Background Simulating the cardiac function requires the numerical solution of multi-physics
and multi-scale mathematical models. This underscores the need for streamlined, accurate …