5-HT receptors expressed throughout the human body are targets for established
therapeutics and various drugs in development. Their diversity of structure and function …

Since our review of central 5-HT receptors and their function twenty years ago, no new 5-HT
receptor has been discovered and there is little evidence that this situation will change in the …

Irritable bowel syndrome (IBS) is an extremely prevalent but poorly understood
gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help …

Neurotransmitter-gated ion channels of the Cys-loop receptor family mediate fast
neurotransmission throughout the nervous system. The molecular processes of …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

EVP-6124,(R)-7-chloro-N-quinuclidin-3-yl) benzo [b] thiophene-2-carboxamide, is a novel
partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs) that was evaluated …

The prefrontal cortex (PFC) is responsible for integrating cortical and subcortical inputs to
execute essential cognitive functions such as attention, working memory planning and …

Background Depression or Major depressive disorder (MDD) is a prolonged condition of
sadness. MDD is the most common mental disorder that affects more than 264 million …

Abstract Serotonin (5‐HT) is a neurotransmitter which exerts both central and peripheral
control on numerous physiological functions such as sleep/wake cycle, thermoregulation …

IBS is the most prevalent functional gastrointestinal disorder and phenotypically
characterized by chronic abdominal discomfort, pain and altered defecation patterns. The …