The integrin family of cell adhesion receptors regulates a diverse array of cellular functions
crucial to the initiation, progression and metastasis of solid tumours. The importance of …

Accumulating evidence indicates that there is extensive crosstalk between integrins and
TGF‐β signalling. TGF‐β affects integrin‐mediated cell adhesion and migration by …

Cellular interactions with the extracellular matrix and with neighboring cells profoundly
influence a variety of signaling events including those involved in mitogenesis, survival, and …

Effective myocardial function depends primarily on oxidative energy production. In humans,
at a heart rate of 60 to 70 beats per minute, the oxygen consumption normalized per gram of …

Background & Aims Mesenchymal stem cells (MSCs) mediate tissue repair and might be
used to prevent or reduce liver fibrosis. However, little is known about the anti-fibrotic factors …

Tenascin-C is an adhesion modulatory extracellular matrix molecule that is highly expressed
in the microenvironment of most solid tumors. High tenascin-C expression reduces the …

The ability to isolate prostate stem cells is essential to explore their role in prostate
development and disease. In vitro prostate colony-and sphere-forming assays were used to …

Signals from dynamic cellular interactions between the extracellular matrix and neighboring
cells ultimately input into the cellular decision-making process. These interactions form the …

Chronic, nonhealing wounds represent a major clinical challenge to practically all
disciplines in modern medicine including dermatology, oncology, surgery, and hematology …

Members of the Smad proteins transmit signals triggered by the ligands of transforming
growth factor (TGF)-β superfamily. Ligand-activated receptors induce phosphorylation of so …