Considerable advances have been made in recent years in understanding the generation
and function of memory T cells. Memory T cells are typically parsed into discreet subsets …

T cells have crucial roles in protection against infection and cancer. Although the trafficking
of memory T cells around the body is integral to their capacity to provide immune protection …

Central memory T (TCM) cells patrol lymph nodes and perform conventional memory
responses on restimulation: proliferation, migration and differentiation into diverse T cell …

Tissue-resident memory CD8+ T cells (TRM cells) are crucial in protecting against
reinvading pathogens, but the impact of reinfection on their tissue confinement and …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that
occupies tissues without recirculating. They provide a first response against infections …

Recent efforts toward an HIV vaccine focus on inducing broadly neutralizing antibodies, but
eliciting both neutralizing antibodies (nAbs) and cellular responses may be superior. Here …

During an infection, T cells can differentiate into multiple types of effector and memory T
cells, which help to mediate pathogen clearance and provide long-term protective immunity …

Tissues such as the skin and mucosae are frequently exposed to microbial pathogens.
Infectious agents must be quickly and efficiently controlled by our immune system, but the …

Following antigen-driven expansion in lymph node, transforming growth factor-β (TGFβ) is
required for differentiation of skin-recruited CD8+ T cell effectors into epidermal resident …