Maternal vascular malperfusion (MVM) of the placental bed represents a recognizable
pattern of placental injury related to altered uterine and intervillous blood flow. MVM consists …

The placenta is a transient organ that forms during pregnancy to support the growth and
development of the fetus. During human placental development, trophoblast cells …

BACKGROUND The placenta is the functional interface between the mother and the fetus
during pregnancy, and a critical determinant of fetal growth and life-long health. In the first …

Fetal growth restriction (FGR) and preeclampsia (PE) are often associated with abnormal
maternal inflammation, deficient spiral artery (SA) remodeling, and altered uteroplacental …

During human pregnancy, the fetal circulation is separated from maternal blood in the
placenta by two cell layers–the fetal capillary endothelium and placental trophoblast. This …

Many common disorders of pregnancy are attributed to insufficient invasion of the uterine
lining by trophoblast, fetal cells that are the major cell type of the placenta. Interactions …

Until recently, trophoblast invasion during human placentation was characterized by and
restricted to invasion into uterine connective tissues and the uterine spiral arteries. The latter …

BACKGROUND Recurrent miscarriage and pre-eclampsia are common reproductive
disorders, but their causes are often unknown. Recent evidence has provided new insight …

Progesterone is well known for its numerous endocrinologic roles in pregnancy but is also
endowed with fascinating immunomodulatory capabilities. It can downregulate the induction …

A branched vascular network is crucial to placental development and is dependent on
factors such as vascular endothelial growth factor (VEGF), placental growth factor (PlGF) …