Endocrine therapies targeting oestrogen action (anti-oestrogens, such as tamoxifen, and
aromatase inhibitors) decrease mortality from breast cancer, but their efficacy is limited by …

For decades, studies of endocrine-disrupting chemicals (EDCs) have challenged traditional
concepts in toxicology, in particular the dogma of “the dose makes the poison,” because …

Of the many conceptual distinctions present in psychology today, the approach-avoidance
distinction stands out as one of, if not the, most fundamental and basic. The distinction …

Hormonal therapy plays a vital part in the treatment of estrogen receptor–positive (ER+)
breast cancer. ER can be activated in a ligand-dependent and independent manner …

Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

The strong anti-inflammatory and immunosuppressive effects of glucocorticoids are
mediated primarily by the cytosolic glucocorticoid receptors. These receptors are members …

Deaths from breast cancer have fallen markedly over the past decade due, in part, to the use
of endocrine agents that reduce the levels of circulating oestrogens or compete with …

Polyamines are aliphatic cations with multiple functions and are essential for life. Cellular
polyamine levels are regulated by multiple pathways such as synthesis from amino acid …

Studies indicate that estrogen receptor (ER) α mediates breast cancer-promoting effects of
estrogens. The role of ERβ in breast cancer is unknown. Elucidating the role of ERβ in the …

Sex steroids are essential for skeletal development and the maintenance of bone health
throughout adult life, and estrogen deficiency at menopause is a major pathogenetic factor …