Genetics in model organisms has progressively broken down walls that previously
separated different disciplines of biology. One example of this holistic evolution is the …

Polypharmacy in older adults is associated with multiple negative consequences that may
affect muscular function, independently from the presence of medical conditions. The aim of …

Heart failure (HF) is a major cause of morbidity and mortality in the Western world. HF is
present in more than 5 million people in the United States, accounting for nearly US $40 …

Prolonged exercise induces cardiovascular drift, which is characterized by decreasing mean
arterial pressure (MAP), stroke volume and heart rate increase. Cardiovascular drift has …

BACKGROUND. Evidence from rodent studies indicates that the sympathetic nervous
system (SNS) regulates bone metabolism, principally via β2-adrenergic receptors (β2-ARs) …

Background: The cyclic AMP (adenosine monophosphate; cAMP)-hydrolyzing protein
PDE4B (phosphodiesterase 4B) is a key negative regulator of cardiac β-adrenergic receptor …

The regeneration potential of the mammalian heart is incredibly limited, as cardiomyocyte
proliferation ceases shortly after birth. β-adrenergic receptor (β-AR) blockade has been …

Objective To map out the studies that have investigated the associations of polypharmacy
and/or potentially inappropriate medication (PIM) use with physical activity and sedentary …

In this study, a simple, green, and reliable method combining vortex-assisted liquid-liquid
microextraction based on in situ formation of a novel hydrophobic natural deep eutectic …

Background Reduced physical function and polypharmacy (PPha) are two highly prevalent
negative effects of aging, which are expected to increase more, since demographic aging is …