The introduction of anti-CD20 monoclonal antibodies such as rituximab, ofatumumab, or
obinutuzumab improved the therapy of B-cell malignancies even though the precise …

Bruton's tyrosine kinase (BTK) regulates multiple important signaling pathways and plays a
key role in the proliferation, survival, and differentiation of B-lineage cells and myeloid cells …

The approval of BTK and PI3K inhibitors (ibrutinib, idelalisib) represents a revolution in the
therapy of B cell malignancies such as chronic lymphocytic leukemia (CLL), mantle-cell …

B-cell receptor (BCR) signaling and T-cell interactions play a pivotal role in chronic
lymphocytic leukemia (CLL) pathogenesis and disease aggressiveness. CLL cells can use …

Recirculation of chronic lymphocytic leukemia (CLL) cells between the peripheral blood and
lymphoid niches plays a critical role in disease pathophysiology, and inhibiting this process …

Despite the known link between obesity and insulin resistance (IR) to chronic low-grade
inflammation, new markers capable of early IR detection are needed. Immune cells are …

This study examined the effectiveness of a DNA vaccine for S. agalactiae that was delivered
by mannose-based polyethyleneimine (Man-PEI). The results showed that Man-PEI/pcDNA …

Letters to the Editor cannot fully explain the~ 2-fold higher CD20 levels in CLL cells from
immune niches. 3, 7 Here we hypothesize that the same factor inducing cell surface IgM in …

Simple Summary Targeted therapies in children with hematological malignancies moderate
the effects of cytotoxic therapy, thus improving survival rates. They have emerged over the …

The molecular pathogenesis of follicular lymphoma (FL) was partially revealed 3 decades
ago, with the discovery of the translocation that brings BCL2 under the influence of …