There has recently been an explosion of interest in the analysis of breath constituents as a
way of monitoring inflammation and oxidative stress in the lungs. Here we review the use of …

Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

Caveolins are important components of caveolae, which have been implicated in vesicular
trafficking and signal transduction. To investigate the in vivo significance of Caveolins in …

Background—Hypoxia-induced pulmonary hypertension is a major cause of morbidity and
mortality. Hypoxia induces pulmonary vasoconstriction, in part, by decreasing endothelial …

Primary pulmonary hypertension is a fatal disease characterized by endothelial dysfunction,
hypercontraction and proliferation of vascular smooth muscle cells (VSMCs), and migration …

Chronic pulmonary hypertension is a serious complication of a number of chronic lung and
heart diseases. In addition to vasoconstriction, its pathogenesis includes injury to the …

There has been intense research into the role nitric oxide (NO) plays in physiological and
pathological mechanisms and its clinical significance in respiratory medicine. Elevated …

In many types of cardiovascular pathophysiology such as hypercholesterolemia and
atherosclerosis, diabetes, cigarette smoking, or hypertension (with its sequelae stroke and …

Chronic hypoxic pulmonary hypertension (PH) is associated with vasoconstriction and
structural remodeling of pulmonary vessels including narrowing of the arterial lumen and …

Chronic lung disease in humans is frequently complicated by the development of secondary
pulmonary hypertension, which is associated with increased morbidity and mortality …