Regulation of airway smooth muscle contraction in health and disease

M Lam, E Lamanna, JE Bourke - Smooth muscle spontaneous activity …, 2019 - Springer
Airway smooth muscle (ASM) extends from the trachea throughout the bronchial tree to the
terminal bronchioles. In utero, spontaneous phasic contraction of fetal ASM is critical for …

Emerging mediators of airway smooth muscle dysfunction in asthma

B Yeganeh, C Xia, H Movassagh… - Pulmonary …, 2013 - Elsevier
Phenotypic changes in airway smooth muscle are integral to the pathophysiological
changes that constitute asthma–namely inflammation, airway wall remodelling and …

PPARγ Ligands Regulate Noncontractile and Contractile Functions of Airway Smooth Muscle: Implications for Asthma Therapy

C Donovan, X Tan, JE Bourke - PPAR research, 2012 - Wiley Online Library
In asthma, the increase in airway smooth muscle (ASM) can contribute to inflammation,
airway wall remodeling and airway hyperresponsiveness (AHR). Targetting peroxisome …

Models to understand contractile function in the airways

P Chitano - Pulmonary pharmacology & therapeutics, 2011 - Elsevier
Although the role of contractile function in the airways is controversial, there is general
consensus on the importance of airway smooth muscle (ASM) as a therapeutic target for …

[图书][B] Platelets and airway remodeling: Mechanisms involved in platelet-induced fibroblast and airway smooth muscle cell proliferation in vitro

ACS Holm - 2010 - search.proquest.com
Airway remodeling is a contributing cause to the pathological structural changes, such as
increased cell proliferation, observed in asthma. Platelets have been found in autopsy …